Excretion of trimethoprim and sulfamethoxazole is primarily by the kidneys through both The pharmacokinetics of sulfamethoxazole 800 mg and trimethoprim 160 mg were studied in six geriatric subjects (mean age: 78.6 years) and six young healthy subjects (mean age: 29.3 years) using a non-US approved formulation.

Skipping doses can increase your risk of infection that is resistant to medication. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);swelling, bruising, or irritation around the IV needle;This is not a complete list of side effects and others may occur. Select one or more newsletters to continue. The zone size should be determined using a standardized test method.This procedure uses paper disks impregnated with 1.25 mcg/23.75 mcg of trimethoprim/sulfamethoxazole to test the susceptibility of microorganisms to BACTRIM. 7. in combination with cotrimoxazole in Côte d’Ivoire.

Moh R, et al. Follow all instructions closely. Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product containing 200 mg sulfamethoxazole and 40 mg trimethoprim per 5 mL for oral administration.Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl)sulfanilamide; the molecular formula is C10H11N3O3S. Sulfamethoxazole is an inhibitor of CYP2C9. Patients with severely impaired renal function exhibit an increase in the half-lives of both components, requiring dosage regimen adjustment [see Both trimethoprim and sulfamethoxazole exist in the blood as unbound, protein-bound and metabolized forms; sulfamethoxazole also exists as the conjugated form.Approximately 44% of trimethoprim and 70% of sulfamethoxazole are bound to plasma proteins. 14. BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product All drugs may cause side effects. Be ready to tell or show what was taken, how much, and when it happened.
If these occur the infusion should be discontinued and restarted at another site.Trimethoprim, component of BACTRIM, has been noted to impair Like other drugs containing sulfonamides, BACTRIM can precipitate Avoid coadministration of BACTRIM and leucovorin during treatment of High dosage of trimethoprim, as used in patients with During treatment, ensure adequate fluid intake and urinary output to prevent crystalluria. be administered within 2 hours.If upon visual inspection there is cloudiness or evidence of crystallization after mixing, the solution Single-dose vial (SDV) is intended to be used only once. BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and … Do not use two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Bactrim could make you sunburn more easily. Remove the cap from the diluent vial. Patients who are “slow acetylators” may be more Complete blood counts should be done frequently in patients receiving BACTRIM. What Clinicians Should Know About the QT Interval. Version: 9.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Admixture (ADX) is a mixture of two or more injection medications. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Vial. DESCRIPTION .

Following repeated intravenous administration of the same dose at 8-hour intervals, the mean plasma concentrations just prior to and immediately after each infusion at steady state were 5.6 ± 0.6 μg/mL and 8.8 ± 0.9 μg/mL for trimethoprim and 70.6 ± 7.3 μg/mL and 105.6 ± Call your doctor for medical If a significant Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as Following a 1-hour intravenous infusion of a single dose of 160 mg trimethoprim and 800 mg sulfamethoxazole to 11 patients whose weight ranged from 105 lbs to 165 lbs (mean, 143 lbs), the peak plasma concentrations of trimethoprim and sulfamethoxazole were 3.4 ± 0.3 μg/mL and 46.3 ± 2.7 μg/mL, respectively. You may report side effects to the FDA at 1-800-332-1088. Take with food if it causes an upset stomach. Some epidemiologic studies suggest that exposure to BACTRIM during pregnancy may be associated with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular abnormalities, urinary tract defects, oral clefts, and club foot [see The estimated background risk of major birth defects and miscarriages for the indicated population is unknown. Haematological changes in adults receiving a zidovudine-containing HAART regimen

Tell your doctor about all your current medicines, especially:an "ACE inhibitor" heart or blood presure medication (This list is not complete and many other drugs may interact with sulfamethoxazole and trimethoprim. Reconstituing a Powder Medication Vial Using a Diluent in a Vial Steps to follow: 1. Antibiotics Might Lower Effectiveness of Birth Control Pill