Following reconstitution, cefpodoxime proxetil oral suspension should be stored in a tight container and is stable for 14 days when refrigerated at 2-8°C; any unused suspension should be discarded after this period. However, for the outpatient treatment of immunocompetent adults with cardiopulmonary disease (congestive heart failure or chronic obstructive pulmonary disease [COPD]) and/or other modifying factors that increase the risk for multidrug-resistant S. pneumoniae or gram-negative bacteria, the ATS recommends a 2-drug empiric regimen consisting of a b-lactam anti-infective (e.g. The frequency of side effects is similar to frequency associated with other oral cephalosporins.Cefotaxime (Abbott/Sanofi-Aventis’s Claforan, generics) is a third-generation, parenteral cephalosporin available for intravenous (IV) or intramuscular (IM) administration. Because of the potential for serious reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.Safety and efficacy in infants less than 2 months of age have not been established.Of the 3338 patients in multiple-dose clinical studies of Cefpodoxime Proxetil film-coated tablets, 521 (16%) were 65 and over, while 214 (6%) were 75 and over. For inpatient treatment of CAP patients who require hospitalization in an ICU or non-ICU patient-care setting, various parenteral regimens are recommended. Although the plasma half-life of cefpodoxime may be slightly longer in geriatric adults than in younger adults, other pharmacokinetic parameters are unaffected and no adjustments in cefpodoxime dosage appear to be necessary in geriatric patients other than those related to renal impairment. There is no evidence that cefpodoxime accumulates in plasma following multiple oral doses (up to 400 mg every 12 hours) in adults with normal renal function. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.

Systemic adverse reactions to cefotaxime have been rare. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. They do not treat viral infections (e.g., the common cold). Prior to initiation of cefpodoxime proxetil therapy, appropriate specimens should be obtained for identification of the causative organism and in vitro susceptibility tests.

In healthy geriatric subjects with normal renal function, cefpodoxime half-life in plasma averaged 4.2 hours and urinary recovery averaged 21% after a 400 mg dose was given every 12 hours for 15 days. For additional information regarding treatment of acute otitis media, see Acute Otitis Media under Uses: Otitis Media, in the Cephalosporins General Statement 8:12.06.Oral cefpodoxime proxetil is used for the treatment of pharyngitis and tonsillitis caused by susceptible S. pyogenes (group A b-hemolytic streptococci). 6.Cefpodoxime Proxetil tablets USP contain Cefpodoxime Proxetil USP equivalent to 100 mg or 200 mg of cefpodoxime activity and the following inactive ingredients: carboxymethylcellulose calcium, croscarmellose sodium, sodium lauryl sulfate, hydroxypropyl cellulose, lactose monohydrate, magnesium stearate and opadry orange. Cefpodoxime, like other cephalosporins, should be administered with caution to patients receiving concurrent treatment with potent diuretics.

In these studies, using very strict evaluability criteria and microbiologic and clinical response criteria at the 4 to 21 day post-therapy follow-up, the following presumptive bacterial eradication/clinical success outcomes (cured and improved) were obtained.Manufactured by : Hospira Healthcare India Pvt.Ltd.,On behalf of : Orchid Healthcare (A Division of Orchid Pharma Ltd.)The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

It will not work for Cefpodoxime is available under the following different brand names: Dosage Considerations – Should be Given as Follows: This document does not contain all possible side effects and others may occur. The mean cefpodoxime TElderly subjects do not require dosage adjustments unless they have diminished renal function. Adverse effects reported in pediatric patients receiving oral cefpodoxime proxetil are similar to those reported in adults receiving the drug and include mild to moderate GI effects (diarrhea, vomiting) and dermatologic effects (rash, urticaria, pruritus).Efficacy and safety of cefpodoxime proxetil in geriatric adults are similar to those observed in younger adults.