Clopidogrel, the generic name for Plavix, is one such antiplatelet medication. After repeated doses of 75 mg Clopidogrel per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects.In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women.After single and repeated oral doses of 75 mg per day, Clopidogrel is rapidly absorbed. Uses of Clopidogrel. Please upgrade your browser or download modern browsers from here! The developmental and health benefits of breastfeeding should be considered along with mother's clinical need for Clopidogrel and any potential adverse effects on the breastfed infant from Clopidogrel or from underlying maternal condition.A randomized, placebo-controlled trial (CLARINET) did not demonstrate a clinical benefit of Clopidogrel in neonates and infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary arterial shunt. I do not understand the relationship between uric acid and clopidogrel. At steady state, the average inhibition level observed with a dose of 75 mg Clopidogrel per day was between 40% and 60%. These drugs are often used to treat similar conditions.Platelets are blood cells that help your blood clot normally. It is used to lower the chance of heart attack or stroke. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). Your doctor may perform a blood test to make sure clopidogrel is right for you.This medicine is not expected to harm an unborn baby. A total of 534 (6.9%) patients in the Clopidogrel group versus 573 (7.4%) patients in the placebo group experienced a primary outcome event (p = 0.22). Our website services, content, and products are for informational purposes only. This drug hasn’t been studied in children and shouldn’t be used in people younger than 18 years.This drug hasn’t been studied in children and shouldn’t be used in people younger than 18 years.This drug can cause serious and sometimes fatal bleeding. Different interactions can cause different effects. It comes with serious risks if you don’t take it as prescribed.If you have to temporarily stop taking clopidogrel, start taking it again as soon as your doctor tells you to. Surgery), MBBS Bachelor of Medicine and Bachelor of Surgery That means you may need to take it with other drugs. Any healthcare provider who treats you should know that you are taking clopidogrel.Store at room temperature away from moisture and heat.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. The clinically important adverse reactions observed in trials comparing Clopidogrel plus aspirin to placebo plus aspirin and trials comparing Clopidogrel alone to aspirin alone are discussed below.In CURE, Clopidogrel use with aspirin was associated with an increase in major bleeding (primarily gastrointestinal and at puncture sites) compared to placebo with aspirin (see Table 1). Medications given to treat a heart attack include: Aspirin. The pink film coating contains hypromellose 2910, iron oxide red, lactose monohydrate, titanium dioxide and triacetin.Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses of Clopidogrel. The active metabolite AUCClopidogrel is extensively metabolized by two main metabolic pathways: one mediated by esterases and leading to hydrolysis into an inactive carboxylic acid derivative (85% of circulating metabolites) and one mediated by multiple cytochrome P450 enzymes.