Cytoxan® (cyclophosphamide for injection, USP) is a sterile white powder containing cyclophosphamide monohydrate. It is used to treat severe forms of lupus, such as those affecting the kidneys or brain.THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. Monthly intravenous Cytoxan (cyclophosphamide) treatment was linked to a lower accumulation of lupus nephritis kidney damage than other induction therapies investigated in a study of Japanese patients.Findings indicated that a complete response to treatment at three months predicted a lower damage accumulation, prompting researchers to suggest that a sustained complete response in early stages of the induction therapy might contribute to lower organ damage.To assess outcomes of different lupus nephritis induction treatments in Japanese patients, researchers at The 64 patients analyzed were treated with one of four approaches: monthly intravenous Cytoxan, low-dose intravenous Cytoxan, tacrolimus, or CellCept (mycophenolate mofetil). The team examined rates of complete response to treatment, relapse rates, and organ damage accumulation over a period of three years.Normal dose and low dose intravenous Cytoxan were the most common treatments, with 22 and 18 patients each receiving the therapies, respectively.

Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Yeah, Cytoxan may be used in treating lupus. Controlled trials have shown that pulse cyclophosphamide is the treatment of choice for patients with moderate to severe proliferative nephritis. Based on randomized controlled trials and long-term observational studies, pulse therapy with CY in combination with methyl-prednisolone (MP) is the “gold standard” of therapy for severe lupus. WebMD does not provide medical advice, diagnosis or treatment. Note: This document contains side effect information about cyclophosphamide.

High-dose: 500-1000 mg/m² IV monthly for 6 doses plus corticosteroids . Find patient medical information for Cytoxan Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. Cytoxan (cyclophosphamide) is a chemotherapy drug that has very powerful effects on reducing the activity of the immune system. Side effects requiring immediate medical attention. Due to its toxicity, it is replaced as soon as possible by less toxic drugs.

Those on CellCept tended to have a later response.Patients treated with tacrolimus also had a larger accumulation of kidney damage at three years than those treated with monthly Cytoxan, who had the lowest damage accumulation of all groups.An analysis that took into account numerous factors showed that a complete response at three months predicted a lower kidney damage accumulation at three years.The team also looked at how side effects of the four treatment approaches differed. Six patients had severe active renal disease at the time of treatment. Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. Major infections were seen in 36.3% of the patients receiving Cytoxan; 50% of those receiving low-dose Cytoxan; 54.5% in the Cellcept group; and 23.1% of tacrolimus-treated patients.Two patients on Cytoxan developed bacterial pneumonia that required hospitalization.

He is based in Tel Aviv, Israel, where he does research at Sheba Medical Center. Before you start taking Cytoxan, be sure to tell your doctor if you:

It is intended for general informational purposes only and does not address individual circumstances. Some of the dosage forms listed on this page may not apply to the brand name Cytoxan.. For the Consumer. The realization of the significant gonadal toxicity intensified the efforts for the development of alternative immunosuppressive agents.

Renal involvement in systemic lupus erythematosus (SLE) carries significant risk of morbidity and mortality, which is related to both disease- and treatment-related complications [1, 2]. You should also know that Cytoxan is carcinogenic.

You should talk to your doctor right away if you experience any of these serious side effects: blood in your urine, fevers, and chills, easy bruising or bleeding, shortness of breath or swelling of the feet and ankles.

Cytoxan is actually a cancer drug, but in lupus patients, it's used to treat serious kidney inflammation (including If you continue to use this site we will assume that you are happy with it. Cytoxan is in a class of drugs known as alkylating agents. It is used to quickly control the disease. Abstract Aggressive immunosuppressive therapy with cyclophosphamidehas improved the outcome of major organ disease in lupus patients. 1, D&C Yellow No. The choice of the right drug is highly individualized.