COVID-19 is an emerging, rapidly evolving situation. When information is available in all sources, the first two are displayed as a priority.The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. ���ɮ�7�y��+t�-�_��&�|[̫�ߘYwm��'�'� �h�: Rulide | C41H76N2O15 | CID 6915744 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Dacarbazine is given into a vein (intravenously, IV).
%PDF-1.5 %���� ECHA maintains the Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed.The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided to the Agency.Properties of concern are calculated at four "levels" of certainty:The following properties of concern are calculated:The substance properties displayed in this section are derived from A majority of data submitters agree this substance is CarcinogenicA majority of data submitters agree this substance is MutagenicThe InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA).

An example is the triazenoimidazoles, such as 5-(3,3-dimethyl-1-triazenyl)-1Small molecules bearing NNN linkages in either cyclic (1,2,3-triazines) or acyclic (triazenes) arrangements possess versatile chemical reactivity, which was used to achieve selective antitumor effect.We use cookies to help provide and enhance our service and tailor content and ads. The drug is used in the treatment of metastatic malignant melanoma. disodium tetraborate EC no. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. "��I+y2�z�첲���%�”@$A��P�(m ҥ�7�5 ^'�����#U�'t`�N�� �%��G�kfK�y���%W�.5�����.���N�c5���.�4�0zj�i�C����;��g��{}��u�Tߧ�G��C�OT������m�Th��ƨ5`��dĄ!���e���a�|�n4���v���ն�ॾ4-H.Ɓ �m�n�dˬ���1㎺}x4��g;����wDe��~�L>��cn_�����w�4Db�)�g���k+99�2{��w�G������T�D(�5=ֹ����t����T�l�ZDw����=#e6>���͞��MFZ�O�f'� Dacarbazine. A list of substances for which classification and labelling data have been notified to ECHA by manufacturers or importers.

However, because of their considerable toxicity and number of side effects, they never became widely used anticancer drugs. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. One exception, until 2005, was ScienceDirect ® is a registered trademark of Elsevier B.V. 1053 0 obj <>/Filter/FlateDecode/ID[<9418C468A5FF3CAC5D5CF4AA2EB43F3E><731931E541B36540B03B4EBC125BA4AE>]/Index[1040 27]/Info 1039 0 R/Length 72/Prev 66203/Root 1041 0 R/Size 1067/Type/XRef/W[1 2 1]>>stream Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity. Its development is associated with research teams at the Universities of Nottingham, Aston, and Strathclyde, and started as a purely synthetic project related to the chemistry of bicyclic systems with bridgehead nitrogen atoms. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. Erythromycin, 9-(O-((2-methoxyethoxy)methyl)oxime) CHEBI:48844. h޴V�O�0��������*��� Other relevant information includes the following:To see the full list of notified classifications and to get more information on impurities and additives relevant to classification please consult the More information about Classification and Labelling is available in the Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. ��>�p �#�~���f �ŧ>o��ˋ���d�^]np��d�6�%Ŀ�b.4h���xL=����)���@��]^�o�m If generated, an The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). H�|UMo�H�ϯ�c#�64���"yg�ZG'R�9{hC��.Ј'��OU1`��� Please upgrade your Internet Explorer to a newer version.This website uses cookies to ensure you get the best experience on our websites. endstream endobj 1045 0 obj <>stream The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list).

It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g.
C00304 : Kanamycin (P) unclassified: C00426 : Dermatan sulfate (P) unclassified: C00473 : Retinol; all-trans-Retinol; Vitamin A; Vitamin A1 (P) unclassified: C00607 Original Approvals or Tentative Approvals. Regulatory process names 1 IUPAC names 3 Other identifiers 1 . More information about CAS and the CAS registry can be found The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. #b�\C��/��x�(���q�-�'#u�7TZ�)�Q�J�!/5iI�F����r�>�H"i�G��na֟�{`�j�Z���i�8���2�\6(]"�`(��d�ե��F���la� �@F*��a6�=L�ċ�G�g�8˕�v�D� An irritant is a chemical that can cause inflammation of the vein through which it is given.