Depakote ER was significantly more effective than placebo in reduction of the Mania Rating Scale (MRS) total score.

1-3. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. Follow the directions on your prescription label and read all medication guides or instruction sheets.

Click DEPAKOTE ER is also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures in adults and children 10 years of age or older, and adjunctively in adults and children 10 years of age or older with multiple seizure types that include absence seizures.DEPAKOTE is indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur either in isolation or in association with other types of seizures. Version: 14.01.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

If you log out, you will be required to enter your username and password the next time you visit. The FDA expanded Depakote uses to include the treatment of manic episodes associated with bipolar disorder. Your reactions could be impaired.Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, Call your doctor at once if you have any of these other side effects:easy bruising, unusual bleeding (nose, mouth, or gums), purple or red pinpoint spots under your skin;confusion, tiredness, cold feeling, vomiting, change in your mental state;blurred vision, double vision, unusual eye movements;This is not a complete list of side effects and others may occur. For complex or partial absence seizures, the starting dose is Depakote 15 mg per kg total per day (about 6.8 mg per pound of body weight total per day). As Depakote dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and/or phenytoin may be affected [see Drug Interactions ]. The recommended initial dose is 750 mg daily in divided doses. and formulary information changes. Complex Partial Seizures. Select one or more newsletters to continue. Depakote is used to treat complex partial seizures, simple and complex absence seizures, as well as acute manic symptoms in patients with bipolar disorder.

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Controlled studies in pregnant women show no evidence of fetal risk.May increase levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in brain; may enhance or mimic action of GABA at postsynaptic receptor sites; may also inhibit sodium and calcium channelsDivalproex sodium is a stable co-ordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship and formed during the partial neutralization of valproic acid with 0.5 equivalent of sodium hydroxideEquivalent oral doses of Depakote (divalproex sodium) products and Depakene (valproic acid) capsules deliver equivalent quantities of valproate ion systemically, although the rate of valproate ion absorption may vary with the formulation administered (liquid, solid, or sprinkle), conditions of use (eg, fasting or postprandial) and the method of administrationThese differences should be of minor clinical importancePeak plasma time: 4 hr (tablet); 3.3 hr (sprinkles); 4-17 hr (ER tablet)Protein bound: Concentration dependent; free fraction increases from ~10% at 40 mcg/mL to 18.5% at 130 mcg/mLProtein binding reduced in the elders, chronic hepatic diseases, renal impairment, or with drug that cause displacement (aspirin)CSF: Approximate unbound concentration in plasma (~10% of total concentration) Vd: 11 L/1.73 m2 (total valproate); 92 L/1.73 m2 (free valproate)Divalproex sodium dissociates to the valproate ion in the GI tractValproate metabolized in liver by glucuronidation (30-50%) and mitochondrial beta-oxidation (40%) <15-20% is eliminated by other oxidative mechanismsTotal body clearance: 0.56 L/hr/1.73 m2 (total valproate); 4.6 L/hr/1.73 m2 (free valproate)Adding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans.

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In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. This medicine is sometimes used together with other seizure medications. Complex absence is the term used when other signs are also present.DEPAKOTE and DEPAKOTE ER are indicated for prophylaxis of migraine headaches.

Your family or other caregivers should also be alert to changes in your mood or symptoms.It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.Take Depakote exactly as prescribed by your doctor.

Your doctor will need to check your progress at regular visits. Products or treatments described on this site are available in the U.S., but may not be available in all other countries.I am a licensed U.S. Healthcare Professional and wish to proceed to the Healthcare Professionals Only AbbVie Medical Information site.©2020 AbbVie Inc.   North Chicago, IL 60064   US-DPKT-200006