Please enable it to take advantage of the complete set of features! Usual cause of elevated INR without anticoagulants is hepatic failure/insufficiency because INR reflects vitamin K-dependent clotting.In terms of a care plan, I'd assume the nursing diagnosis would be Risk for bleeding r/t elevated INR. Ann Pharmacother. Could be vitamin k deficiency. Some natural health products and other medicines can make warfarin work too well.

Elevated INR related to leg wound? Unable to load your delegates due to an error They decrease blood clotting to decrease the chances of a clot in the heart from causing stroke or clot in a vein traveling to the lungs by preventing it from growing larger while the body's natural processes break it down for disposal.

There is some difficulty in deciding a starting dosage of warfarin, because of the large interindividual variation in the dose needed to reach adequate level of INR. Specializes in CTICU.

If the patient is on antibiotics for leg wound that will send INR wacky, usually elevating it to critical levels. reply #4.

The fluvastatin was switched back to atorvastatin, and the warfarin dosage was increased to maintain the patient's goal INR. However, warfarin has a narrow therapeutic range of international normalized ratio (INR) and is known to have multiple interactions with drugs, food, and herb.

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Specializes in ER/ICU/STICU. Althought this thread is about 2 years old....That an excelent thought.....we are always learning!

The INR goal for people who take warfarin is usually from 2 to 3. Was this pt septic?

Source of this information?And please...never, ever use the term "blood thinner.

2009 Jul;43(7):1347-53. doi: 10.1345/aph.1M064. The diagnosis is elevated INR rt leg wound.

By Xena, 4 years ago on Heart attacks & diseases. The problem then becomes that they are not aware of the actual physiological reason their medications are prescribed to reduce risk for embolic events, either stroke or deep vein thrombosis and pulmonary embolus. Side effects include easier bruising and bleeding. That may be why the leg wound is mentioned.

Anticoagulants do not "thin" the blood. I have been looking up INR and everything talks about warfarin and blood thinners, but the patient isn't on any. Welcome to AN! If the patient is on antibiotics for leg wound that will send INR wacky, usually elevating it to critical levels. The literature supports a drug interaction between warfarin and fluvastatin due to the strong affinity of fluvastatin for the cytochrome P450 enzyme 2D6. Also, I think saying 'elevating it to critical levels' is a bit hyperbolic.

Specializes in Emergency, Telemetry, Transplant. Our mission is to Empower, Unite, and Advance every nurse, student, and educator.

I am very confused and appreciate any insight you may have for me.

Specializes in Critical Care, ED, Cath lab, CTPAC,Trauma. This interaction has not been seen with atorvastatin. I'm presuming what she meant is that the antibiotic will kill/inhibit the growth of bacteria, particularly in the large intestine, that produce Vitamin K. However, I have only heard of this being an issue (i.e. The risk of discontinuing the medication because the effects are inaccurately communicated is great, and very real.

"Many people including, alas, physicians and nurses who know better, refer to anticoagulation medications (both antiplatelet and those acting on other parts of the clotting cascade) as "blood thinners." With a wound I might suspect possible DIC related to sepsis, but I would anticipate the patient being much more sick and have a diagnosis of sepsis. So I need some help doing a care plan.

If anyone knows what can cause elevated INR in an otherwise seemingly healthy person, it would be good to know because it is hard to find any answers not relating to warfarin. What antibiotic does that? It's hard to say with the limited information. Extended-release niacin 500 mg daily had not affected the patient's INR for the previous 3 months; the most recent INR before this episode was 2.4. I have been looking up INR and everything talks about warfarin and blood thinners, but the patient isnt on any. On the eighth day of daptomycin therapy (hospital day 21), the INR remained elevated (2.6) even though the patient had not been exposed to warfarin for 9 days.

Atypon

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2009 Jun;29(6):744-8. doi: 10.1592/phco.29.6.744.Ann Pharmacother. Source of this information? doi: 10.1345/aph.1Q217. Thanks,Angel

What you're saying makes more sense that what Ive been reading. elevated INR) in the setting of warfarin use.

A value higher than 3.5 increases the risk of bleeding problems. There, is that so hard?What antibiotic does that? Thanks for your help. allnurses is Registered ® Copyright © allnurses.com