If the administration of metronidazole cannot be separated from the hemodialysis session, supplementation of metronidazole dosage following the hemodialysis session should be considered, depending on the patient's clinical situation (see Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The presence of bacterial vaginosis had no significant impact this result (p=0.17 for interaction). Untreated, this can lead to poor reproductive outcomes and increased rates of HIV transmission. Overall, this study supports the use of a 7-day-dose of metronidazole rather than a single-dose for women with trichomoniasis. Among women, NAAT is highly sensitive, often detecting three to five times more T. vaginalis infections than wet-mount microscopy, a method with poor sensitivity (51%–65%) (663,664). The APTIMA T. vaginalis assay (Hologic Gen-Probe, San Diego, CA) is FDA-cleared for detection of T. vaginalis from vaginal, endocervical, or urine specimens from women. 1971 Dec; 47 (6):456–458. In most instances, trichomoniasis is asymptomatic in men and women. Researchers found that the proportion of women who tested positive for trichomoniasis at 4 weeks was lower in the 7-day dose group than in the single-dose group (11% vs. 19%, RR 0.55, 95% CI 0.34 to 0.70, p<0.0001). The clearance of metronidazole will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. Loading dose: 15 mg/kg IV once as a single dose. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. In The Female. Saving Lives, Protecting People Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Take this medicine only as directed by your doctor. The dose of this medicine will be different for different patients. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. © Copyright 2 Minute Medicine, Inc. All rights reserved. That’s right; one pill and boom! The use of highly sensitive and specific tests is recommended for detecting T. vaginalis. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears … “The 7-day-dose metronidazole should be the preferred treatment for trichomoniasis among women,” the study concludes. Comments: -Most serious anaerobic infections are treated with IV therapy initially. The dose is usually 7.5 milligrams (mg) per kilogram (kg) of body weight every 6 hours for 7 to 10 days. To avoid getting reinfected, make sure that all of your sex partners get treated too, and wait to have sex again until all of your symptoms go away (about a week). This assay detects RNA by transcription-mediated ampli… 500 mg for a 70-kg adult). All rights reserved. Total and differential leukocyte counts should be made before and after re-treatment.Treatment should be individualized as it is for the female.In the treatment of most serious anaerobic infections, intravenous metronidazole is usually administered initially.The usual adult oral dosage is 7.5 mg/kg every six hours (approx. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Trichomonal vaginitis treated with one dose of metronidazole. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Limitations of this study included its open-label design and low enrollment. It is okay for pregnant women to take this medication. Adherence to treatment was lower in the 7-day-dose group than in the single-dose group (96% vs. 99% respectively, p=0.006). Although a single, 2-gm dose of metronidazole has been approved for the treatment of vaginal trichomoniasis, this regimen has not gained general acceptance. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. One-day treatment – two grams of FLAGYL, given either as a single dose or in two divided doses of one gram each, given in the same day. To determine the minimum effective dose of metronidazole in the treatment of vaginal trichomoniasis, a randomised clinical trial comparing single 1-g and 2-g doses was carried out on 163 patients attending sexually transmitted diseases and family planning clinics.