Drug interactions are reported among people who take Promethazine and Haldol together. Unable to load your delegates due to an error The effects of histamine H1-receptor antagonists, promethazine and homochlorcyclizine, both of which are inhibitors of CYP2D6, on the steady-state plasma concentrations (Css) of haloperidol and reduced haloperidol were studied in 23 schizophrenic inpatients receiving haloperidol, 12 to 36 mg/d, for 2 …


Thus, the current study suggests that coadministration of clinical doses of promethazine and homochlorcyclizine increases the Css of haloperidol and reduced haloperidol via the inhibitory effects on the CYP2D6-catalyzed metabolism of haloperidol and reduced haloperidol. COVID-19 is an emerging, rapidly evolving situation. Blood sampling was performed before and during coadministration of promethazine or homochlorcyclizine and 1 week after the discontinuation, together with clinical assessments by Brief Psychiatric Rating Scale (BPRS) and Udvalg for kliniske undersogelser (UKU) side effect rating scale.

Promethazine, 150 mg/d, in 11 patients and homochlorcyclizine, 60 mg/d, in the others were coadministered for at least 1 week. This site needs JavaScript to work properly. Co-administration of citalopram and escitalopram with drugs that prolong the QT interval (such as antipsychotics including haloperidol) is contraindicated [ … These medications are not usually taken together. Epub 2011 Jun 22.World J Gastroenterol. Coadministration of clinical doses of promethazine (150 mg/d) significantly increased (2-fold) the steady state plasma concentrations of haloperidol and reduced haloperidol via inhibitory effects on the CYP2D6-catalyzed metabolism of haloperidol and reduced haloperidol.

The study is created by eHealthMe based on reports of 44 people who take Promethazine and Haldol from the FDA, and is updated regularly. Haloperidol is an inhibitor of CYP2D6. Amiodarone has a long half-life; there is a potential for drug interactions to occur for several weeks (or even months) after treatment has been stopped. The effects of histamine H1-receptor antagonists, promethazine and homochlorcyclizine, both of which are inhibitors of CYP2D6, on the steady-state plasma concentrations (Css) of haloperidol and reduced haloperidol were studied in 23 schizophrenic inpatients receiving haloperidol, 12 to 36 mg/d, for 2 to 29 weeks. Clipboard, Search History, and several other advanced features are temporarily unavailable.

Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine. Wolters Kluwer The Css of haloperidol and reduced haloperidol during homochlorcyclizine coadministration (14.9 +/- 8.1 and 6.4 +/- 5.4 ng/mL) were also significantly higher than those before the coadministration (10.9 +/- 7.2 and 3.8 +/- 3.6 ng/mL; P < 0.01) or 1 week after the discontinuation (12.9 +/- 7.4 and 4.8 +/- 4.1 ng/mL; P < 0.05).

Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. ... nefazodone, buspirone, venlafaxine, alprazolam, fluvoxamine, quinidine, fluoxetine, sertraline, chlorpromazine, and promethazine. Formation of reduced haloperidol is catalyzed by a ketone reductase. 1999 Jun;21(3):297-300. doi: 10.1097/00007691-199906000-00007.Midha KK, Hubbard JW, Marder SR, Marshall BD, Van Putten T.Vares M, Saetre P, Strålin P, Levander S, Lindström E, Jönsson EG.Hum Psychopharmacol.

Severe Interactions.

* Approximation only. Br J Psychiatry 2004;185:63–9.
1999 Jul;145(2):189-92. doi: 10.1007/s002130051048.Suzuki A, Otani K, Ishida M, Yasui N, Kondo T, Mihara K, Kaneko S, Inoue Y.Prog Neuropsychopharmacol Biol Psychiatry. The Css (mean +/- SD) of haloperidol and reduced haloperidol during promethazine coadministration (27.6 +/- 24.9 and 8.6 +/- 13.2 ng/mL) were significantly higher than those before the coadministration (12.7 +/- 10.8 and 5.0 +/- 6.0 ng/mL; P < 0.01) or 1 week after the discontinuation (15.6 +/- 14.8 and 5.8 +/- 7.9 ng/mL; P < 0.05). Alexander J, Tharyan P, Adams C, et al .