In many cases the signs of infection such as fever and white blood cell count were reduced.

Monitoring of clozapine levels is essential during hospitalisation for infection and consideration should be given to gradual dose reduction to minimise dose related side effects.We use cookies to help provide and enhance our service and tailor content and ads. When interpreting blood levels, low clozapine levels can result from low dose, non-adherence, or rapid metabolism. Epub 2012 Jul 23.Dotson S, Hartvigsen N, Wesner T, Carbary TJ, Fricchione G, Freudenreich O.Psychosomatics. In addition, 8 new cases from two Australian states were included. 40 cases were identified in 23 publications that demonstrated elevated clozapine levels associated with infection.

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2020 Jun;46(3S):S126-S127. to bring plasma clozapine below 1.0 …

Elsevier Science Epub 2018 Mar 27.Am J Ther.

2016 Aug;42(4):346-53. doi: 10.1016/j.encep.2016.03.005. Unable to load your collection due to an error
Most agree that clozapine levels provide the most value, while others suggest norclozapine levels should also be considered.

doi: 10.1136/gpsych-2019-100183. Clozapine at toxic doses may cause hyperthermia, alterations in consciousness, seizures, cardiac arrhythmias, excessive mucus production in bronchi, hypersalivation, miosis, blood dyscrasias, pancreatitis and hepatitis (Sartorius et al., 2002). Clozapine is an antipsychotic drug indicated for treatment-resistant schizophrenia. A total of 54 articles with a total of 109 individual case reports were obtained by manual and computerised literature search from January 1970 to May 2013. Adverse events, typically sedation, were associated with raised clozapine levels during infection.

Severe adverse effects were uncommon, with one case each of seizure, myocarditis and neutropenia. Online ahead of print.Bouaziz N, Ben Rejeb H, Ateb S, Fourati T, Chammas F, Baha D, Rosetti R, Kalalou K, Saba G, Benadhira R, Januel D.Encephale. Demographics, psychiatric diagnoses and medical morbidities, medications, clinical symptoms, clozapine levels, inflammatory markers and final clinical outcome were extracted.

Clozapine blood levels are influenced by age, gender, ethnicity, physical illnesses like liver failure, changes in the activity of the cytochrome oxidase enzymes due to genetic variability, co… Clozapine is the most effective anti-psychotic medication for treatment refractory schizophrenia. 25 mg/d in week 1, further 25 mg/d in week 2, etc.)

If a clozapine level is high, check the …


Clipboard, Search History, and several other advanced features are temporarily unavailable. Severe adverse effects were uncommon, with one case each of seizure, myocarditis and neutropenia.

By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. A growing number of case reports have linked infection to high clozapine levels and associated adverse outcomes. We present a systematic review of published cases to clarify the relationship between infection and elevated clozapine levels.



2020 May 30:S0033-3182(20)30179-1. doi: 10.1016/j.psym.2020.05.025. Demographics, psychiatric diagnoses and medical morbidities, medications, clinical symptoms, clozapine levels, inflammatory markers and final clinical outcome were extracted. Note that the norclozapine level is ignored for this calculation. Severe adverse effects were uncommon, with one case each of seizure, myocarditis and neutropenia.

In addition, 8 new cases from two Australian states were included. Only some of these side effects are thought to be related to the clozapine serum level, including sedation, delirium, seizures, arrhythmias, hypotension, aspiration, and respiratory depression (Stark and Scott, 2012). Adverse events, typically sedation, were associated with raised clozapine levels during infection.

A growing number of case reports have linked infection to high clozapine levels and associated adverse outcomes. ScienceDirect ® is a registered trademark of Elsevier B.V.Elevated clozapine levels associated with infection: A systematic reviewCrown Copyright © 2017 Published by Elsevier B.V. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Infections were commonly respiratory in origin. Epub 2020 May 21.Psychosomatics.