You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Take nifedipine exactly as directed. Nifedipine should not be used to rapidly drop blood pressure as this may be fatal.Medicines that interact with nifedipine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with nifedipine. Information is also available online at Keep all appointments with your doctor and the laboratory. For example, the high from LSD lasts 6 to 12 hours, but the high from cocaine lasts about 15-30 minutes. Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations.The precise mechanisms by which inhibition of calcium influx relieves angina has not been fully determined, but includes at least the following two mechanisms:Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. Addos 4. It has a molecular weight of 346.33. Your doctor will probably start you on a low dose of nifedipine and gradually increase your dose, generally once every 7 to 14 days. NIFEDIPINE (nye FED i peen) is a calcium-channel blocker. Since steady-state plasma levels are achieved on the second day of dosing, titration may proceed more rapidly, if symptoms so warrant, provided the patient is assessed frequently. Some items may interact with your medicine.Visit your doctor or health care professional for regular check ups. Also tell them if you smoke, drink alcohol, or use illegal drugs. You may need to stop using the medicine at least 36 hours before surgery. Do not stand or sit up quickly, especially if you are an older patient. Since there have been isolated reports of patients with elevated digoxin levels, it is recommended that digoxin levels be monitored when initiating, adjusting, and discontinuing nifedipine to avoid possible over- or under-digitalization.There have been rare reports of increased prothrombin time in patients taking coumarin anticoagulants to whom nifedipine was administered. When given to rats prior to mating, nifedipine caused reduced fertility at a dose approximately 5 times the maximum recommended human dose. In an uncontrolled study of over two hundred patients with congestive heart failure during which digoxin blood levels were not measured, digitalis toxicity was not observed. Nifedipine Extended-release Tablet may also be used where the clinical presentation suggests a possible vasospastic component, but where vasospasm has not been confirmed, e.g., where pain has a variable threshold on exertion, or in unstable angina where electrocardiographic findings are compatible with intermittent vasospasm, or when angina is refractory to nitrates and/or adequate doses of beta-blockers.Nifedipine Extended-release Tablet is indicated for the management of chronic stable angina (effort-associated angina) without evidence of vasospasm in patients who remain symptomatic despite adequate doses of beta-blockers and/or organic nitrates or who cannot tolerate those agents.In chronic stable angina (effort-associated angina), nifedipine has been effective in controlled trials of up to eight weeks duration in reducing angina frequency and increasing exercise tolerance, but confirmation of sustained effectiveness and evaluation of long-term safety in these patients is incomplete.Controlled studies in small numbers of patients suggest concomitant use of nifedipine and beta-blocking agents may be beneficial in patients with chronic stable angina, but available information is not sufficient to predict with confidence the effects of concurrent treatment, especially in patients with compromised left ventricular function or cardiac conduction abnormalities. Nifedipine is in a class of medications called calcium-channel blockers. The effect may be mediated by the known inhibition of cimetidine on hepatic cytochrome P-450, the enzyme system probably responsible for the first-pass metabolism of nifedipine. Vitamin D is so important I wrote a four part series on it.