Therefore, and solely to indicate this fact, this article is hereby marked “advertisement” in accordance with 18 USC section 1734.We thank the staff of the Thalassemia Center of Laikon General Hospital, the referring physicians for their contribution and valuable discussion, and above all, the participating patients and their families.Contribution: E.V. Search for other works by this author on: Search for other works by this author on: Lean Library can solve it Go to Top of … The clinical significance of this observation is unknown.

Phenothiazines may potentiate the CNS and respiratory depression in these patients.Major Potential Hazard, High plausibility.

However, patients may infrequently develop symptoms after relatively brief treatment periods at low dosages. Factors studied in the univariate analysis for predicting survival in patients who did not receive HUAll parameters were evaluated as continuous variables.CI indicates confidence interval; HU, hydroxyurea; and LDH, lactate dehydrogenase.Multivariate analysis (Cox regression) in non-HU patientsAll parameters were evaluated as continuous variables.CI indicates confidence interval; HbF, hemoglobin F; HU, hydroxyurea.HU is the only available drug to date that alters the process and prognosis of SCD. Toxicity was graded according to the National Cancer Institute Common Terminology Criteria Version 2.0.Data were analyzed as of July 2008.

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Phenothiazine therapy should not be initiated in patients with active NMS and should be immediately discontinued if currently being administered in such patients. Search for other works by this author on: Propylamino derivatives such as chlorpromazine, promazine, and triflupromazine may be more likely to induce these effects. Cholestatic jaundice usually occurs between the second and fourth weeks of therapy in approximately 0.1% to 4% of all patients. International Agency for Research on Cancer.

Applies to: CNS DisorderPhenothiazines can lower the seizure threshold and induce seizures, particularly when dosages are high or increased rapidly and during the initiation of therapy. The Mann-Whitney Since 1991, 330 patients (136 men/194 women; median age, 42 years; range, 20-76 years) were followed-up in the Thalassemia Center of Laikon General Hospital in Athens, Greece.

While its use is rarely associated with adverse effects secondary to dopaminergic blockade, large doses have produced extrapyramidal reactions. HU produced lower death rate as the result of liver dysfunction (0.7% vs 5%), although the incidence of liver impairment at baseline was similar between HU and non-HU patients (28.6% and 27.5%, respectively). Simply select your manager software from the list below and click on download. January 2007.Hodgkin's disease in a child with sickle cell disease treated with hydroxyurea.Clinical response and adverse events in young patients with sickle cell disease treated with hydroxyurea.Prolonged administration of hydroxyurea reduces morbidity and mortality in adult patients with sickle-cell syndromes: long-term experience of a single center [abstract].

Informed consent was obtained from all patients before inclusion in the study in accordance with the Declaration of Helsinki.

During chronic administration and/or high-dose therapy, the usual contraindications, warnings and precautions applicable to phenothiazines should be observed with promethazine.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Applies to: Neuroleptic Malignant SyndromeThe central dopaminergic blocking effects of phenothiazines may precipitate or aggravate a potentially fatal symptom complex known as Neuroleptic Malignant Syndrome (NMS). The feeling of better amelioration of general clinical condition of patients under HU in the MSH study is in accordance with our study in which HU patients have reported a better performance status from the first month of HU administration, although this has not been confirmed by a quality of life questionnaire-based measurement.

HU also reduced dramatically the serum levels of bilirubin, LDH, transaminases and γGT and thus produced a beneficial effect on liver function. Response was defined as 2-fold increase of HbF levels after 6 months of HU treatment compared with baseline HbF values and improvement of clinical status with reduction of painful crisis for at least 50% within 12 months of HU administration.All patients who received at least 1 month of HU therapy were eligible for assessment of toxicity. Applies to: Tardive DyskinesiaPhenothiazines may commonly precipitate symptoms of tardive dyskinesia (TD), a syndrome consisting of rhythmic involuntary movements variously involving the tongue, face, mouth, lips, jaw, and/or trunk and extremities, following chronic use of at least several months but often years.