The most serious ADRs were serious allergic reactions, cardiac failure/congestive heart failure/pulmonary oedema, pancreatitis, serious hepatotoxicity (including some cases of fatal acute liver failure), and serious skin reactions. In a rat carcinogenicity study hydroxypropyl-β-cyclodextrin produced adenocarcinomas in the large intestine and exocrine pancreatic adenocarcinomas. Calcium channel blockers can have negative inotropic effects which may be additive to those of itraconazole. Talk to your doctor if you have a pre-existing heart condition. The exposure of itraconazole may be lower in some patients with renal insufficiency and a wide intersubject variation was observed in these subjects receiving the capsule formulation (see section 5.2). (See sections 4.2 Posology and method of administration and 4.4 Special warnings and special precautions for use).Limited data are available on the use of oral itraconazole in patients with renal impairment.

When appropriate, it is recommended that itraconazole plasma concentrations be measured.Itraconazole and its major metabolite, hydroxy-itraconazole can inhibit the metabolism of drugs metabolised by the cytochrome 3A family (CYP3A4) and can inhibit the drug transport by P-glycoprotein which may result in increased plasma concentrations of these drugs and/or their active metabolite(s) when they are administered with itraconazole.
Steady-state concentrations are generally reached within about 15 days, with Cmax values of 0.5 μg/ml, 1.1 μg/ml and 2.0 μg/ml after oral administration of 100 mg once daily, 200 mg once daily and 200 mg b.i.d., respectively. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Peak plasma concentrations of the unchanged drug are reached within 2 to 5 hours following an oral dose. Hepatic Impairment Motilium is contraindicated in … Motilium Tablets are indicated for the relief of the symptoms of nausea and vomiting. Itraconazole was found to cause a dose-related increase in maternal toxicity, embryotoxicity and teratogenicity in rats and mice at high doses. As re-distribution of itraconazole from keratinous tissues appears to be negligible, elimination of itraconazole from these tissues is related to epidermal regeneration. These patients received at least one dose of itraconazole for prophylaxis of fungal infections or for treatment of oral thrush or systemic fungal infections and provided safety data.

Itraconazole oral solution (liquid) is used to treat yeast infections of the mouth and throat or of the esophagus (tube that connects the throat to the stomach). Similarly, itraconazole may modify the pharmacokinetics of other substances that share this metabolic pathway. Effective contraception should be continued until the menstrual period following the end of Itraconazole 100mg Capsules, hard therapy.A very small amount of itraconazole is excreted in human milk. Several of these reports included concurrent administration of quinidine which is contraindicated (see section 4.5). Domperidone Domperidone has the following chemical structure. • Itraconazole capsules should not be administered to patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections (see section 4.4). It has also a marked affinity for lipids. If coadministration cannot be avoided, clinical monitoring for signs or symptoms of increased or prolonged effects or side effects of the interacting drug is recommended, and its dosage be reduced or interrupted as deemed necessary.