Glipizide is used together with diet and exercise to improve blood sugar control in … If your blood sugar level is not under control, call your healthcare provider. Markedly reduced GI retention times of the GLUCOTROL XL tablets over prolonged periods (e.g., short bowel syndrome) may influence the pharmacokinetic profile of the drug and potentially result in lower plasma concentrations. The mean apparent volume of distribution was approximately 10 liters. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. In 12 week, well-controlled studies, there was a maximal average net reduction in hemoglobin A 1C of 1.7% in absolute units between placebo-treated and GLUCOTROL XL-treated patients. At such times, it may be necessary to discontinue glipizide and administer insulin.The effectiveness of any oral hypoglycemic drug, including glipizide, in lowering blood glucose to a desired level decreases in many patients over a period of time, which may be due to progression of the severity of the diabetes or to diminished responsiveness to the drug. Glipizide oral tablet is available as both a generic and brand-name drug. Those patients who may be more sensitive to hypoglycemic drugs may be started at a lower dose.Dosage adjustment should be based on laboratory measures of glycemic control. In some cases, especially when the patient has been receiving greater than 40 units of insulin daily, it may be advisable to consider hospitalization during the transition period.As with other sulfonylurea-class hypoglycemics, no transition period is necessary when transferring patients to GLUCOTROL XL Extended Release Tablets. May 11, 2010 Read the information you get with your medicine each time you refill your prescription. GLUCOTROL XL or Glucotrol® for 8 weeks and then crossed over to the other drug for an additional 8 weeks. Do not change your dose without your healthcare provider's approval.In case of overdose, call the poison control center or your healthcare provider right away, or have someone drive you to the nearest emergency room.You must continue your diet and exercise program while taking GLUCOTROL XL.

Therapy with a combination of glucose-lowering agents may increase the potential for hypoglycemia.When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma, infection, or surgery, a loss of control may occur. Glucotrol XL is a sulfonylurea drug produced by the Pfizer company and suggested to people with type 2 diabetes to keep their blood sugar level level under control. There may be new information.

54868-3335-1, Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. In post marketing reports, hemolytic anemia has also been reported in patients who did not have known G6PD deficiency.Blood and urine glucose should be monitored periodically. Your healthcare provider has prescribed GLUCOTROL XL because your current treatment, including diet and exercise, has not been able to bring your blood sugar level under good control.Your body makes insulin to keep the amount of sugar (glucose) in your blood at the right level. Several days should elapse between titration steps.During the insulin withdrawal period, the patient should test urine samples for sugar and ketone bodies at least three times daily. The mean relative bioavailability of glipizide in 21 males with type 2 diabetes after administration of 20 mg GLUCOTROL XL Extended Release Tablets, compared to immediate release Glucotrol (10 mg given twice daily), was 90% at steady-state. Elderly, debilitated or malnourished patients, and those with adrenal or pituitary insufficiency are particularly susceptible to the hypoglycemic action of glucose-lowering drugs. In 2 randomized, double-blind, dose-response studies comprising a total of 347 patients, there was no significant increase in fasting insulin in all GLUCOTROL XL-treated patients combined compared to placebo, although minor elevations were observed at some doses. There have been rare reports of obstructive symptoms in patients with known strictures in association with the ingestion of another drug in this non-deformable sustained release formulation.There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with GLUCOTROL XL or any other anti-diabetic drug.The pharmacokinetics and/or pharmacodynamics of glipizide may be affected in patients with impaired renal or hepatic function. Brand names: Glucotrol and Glucotrol XL. However, since glipizide is highly protein bound and hepatic biotransformation is the predominant route of elimination, the pharmacokinetics and/or pharmacodynamics of glipizide may be altered in patients with renal or hepatic impairment.In mice no glipizide or metabolites were detectable autoradiographically in the brain or spinal cord of males or females, nor in the fetuses of pregnant females. In a single dose, food effect study in 21 healthy male subjects, the administration of GLUCOTROL XL immediately before a high fat breakfast resulted in a 40% increase in the glipizide mean Cmax value, which was significant, but the effect on the AUC was not significant. The major metabolites of glipizide are products of aromatic hydroxylation and have no hypoglycemic activity. 54868-3334-0, They should also be informed about the importance of adhering to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members.