Tell your doctor about all your current medicines and any you start or stop using, especially:drugs to treat high blood pressure or a prostate disorder--This list is not complete. Concomitant administration of drugs that inhibit this enzyme (e.g. Take your last dose of the day within 3 or 4 hours before bedtime.Take this medicine during your normal waking hours, when your are most likely to be upright and not lying down or napping. Follow your doctor's instructions very closely.Store at room temperature away from moisture and heat.Take the missed dose as soon as you remember. At present, however, clinical benefits of Midodrine hydrochloride tablets, principally improved ability to perform life activities, have not been established. Because many drugs are excreted in human milk, caution should be exercised when Midodrine hydrochlorideSafety and effectiveness in pediatric patients have not been established.The most frequent adverse reactions seen in controlled trials were supine and sitting hypertension; paresthesia and pruritus, mainly of the scalp; goosebumps; chills; urinary urge; urinary retention and urinary frequency.The frequency of these events in a 3-week placebo-controlled trial is shown in the following table: Less frequent adverse reactions were headache; feeling of pressure/fullness in the head; vasodilation/flushing face; confusion/thinking abnormality; dry mouth; nervousness/anxiety and rash. Mechanism of Action: Midodrine hydrochloride forms an active metabolite, desglyMidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. Midodrine is used to treat low blood pressure (hypotension) that causes severe dizziness or a light-headed feeling, like you might pass out. Midodrine works by constricting (narrowing) the blood vessels and increasing blood pressure.Midodrine may also be used for purposes not listed in this medication guide.You should not use midodrine if you have severe heart disease, overactive thyroid, an adrenal gland tumor, kidney disease, if you are unable to urinate, or if your blood pressure is high even while lying down.Midodrine can increase blood pressure even when you are at rest.

One patient ingested Midodrine hydrochloride The single doses that would be associated with symptoms of overdosage or would be potentially life-threatening are unknown. Patients who experience any signs or symptoms suggesting bradycardia (pulse slowing, increased dizziness, syncope, cardiac awareness) should be advised to discontinue Midodrine hydrochloride and should be re-evaluated.Midodrine hydrochloride use has not been studied in patients with renal impairment. Check your blood pressure while you are lying down, and check it again with your head elevated.Your kidney and liver function may also need to be checked.Midodrine is only part of a treatment program that may also include lifestyle changes, wearing support stockings on your legs, and possibly special medical care. It is essential to monitor supine and sitting blood pressures in patients maintained on Midodrine hydrochloride. The patient should be cautioned to report symptoms of supine hypertension immediately. Available for Android and iOS devices. Symptoms may include cardiac awareness, pounding in the ears, headache, blurred vision, etc. Caution should be exercised when Midodrine hydrochloride is used concomitantly with cardiac glycosides (such as digitalis), psychopharmacologic agents, beta blockers or other agents that directly or indirectly reduce heart rate. Select one or more newsletters to continue. After week 1, Midodrine-treated patients had small improvements in dizziness/lightheadedness/unsteadiness scores and global evaluations, but these effects were made difficult to interpret by a high early drop-out rate (about 25% vs 5% on placebo). Thus there may be a potential for drug-drug interactions with these drugs.Long-term studies have been conducted in rats and mice at dosages 3 to 4 times the maximum recommended daily human dose on a mg/mIt is not known whether this drug is excreted in human milk. There is no experience in patients with initial supine systolic pressure above 180 mmHg, as those patients were excluded from the clinical trials.