This review investigates the efficacy, side effects, and safety of three commonly prescribed skeletal muscle relaxants metaxalone (Skelaxin), cyclobenzaprine (Flexeril), and carisoprodol (Soma).Muscle relaxants are not really a class of drugs, but rather a group of different medications that produce an overall sedative effect on the body.Muscle relaxants treat both muscle spasm and spasticity. Skeletal muscle relaxants are commonly prescribed for the treatment of muscle spasms and discomfort. (8%).Metaxalone has the fewest reported side effects of any skeletal muscle 0 These medications should be used with caution in people driving motor particularly confusion, lethargy, and anticholinergic side effects, and Whether from a new injury or an aggravated old injury, stiffness and soreness in the neck and back at night may lead to disrupted sleep and more pain in the morning. 2788 0 obj <> endobj h�bbd``b`k�� ��
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Muscle relaxants have been shown to help relieve this pain and get you through these tough daysused at night, these medications may improve acute neck and back pain. have indicated they may be more effective in combination with analgesics.When there is no a clearly superior agent, side effect profiles and cost become a significant factor in the selection of muscle relaxers.

was more frequent with cyclobenzaprine (38% vs. 10%) and dizziness less n}�ֲb9��ͼ��~�����rr0p4� ��EGGG#�d`� 1%:�����A����,��Iu�TY�`m,@���dP��Cr40U��3Z���� �H;����L�@���Q������!�����]���/�p10����n����o[$�d1�ծ� V> ���ִHK20��` �-�fP�ic`WR��c�0 t�� Muscle relaxants may be initially frequent (8% vs. 26%). Although grouped under a single drug class, skeletal muscle relaxants are a heterogeneous group of structurally unrelated medications with variable pharmacologic and safety profiles. do exist to the use of carisoprodol and cyclobenzaprine. and other measures for the relief of discomforts associated with acute,

All rights reserved. A comparison of the skeletal muscle relaxants is presented in Table 1. Metaxalone is considered to be less sedating in comparison with carisoprodol and cyclobenzaprine.Carisoprodol is contraindicated in patients with a history of acute intermittent porphyria.Cyclobenzaprine is contraindicated in patients with hyperthyroidism, congestive heart failure, and other heart conductions.Metaxalone is contraindicated in drug-induced, hemolytic or other anemias and in significantly impaired renal or hepatic function.The centrally acting skeletal muscle relaxants have been shown to be
2794 0 obj <>/Filter/FlateDecode/ID[<26B6E88F75485A4D960F3251EBAFB464><90FB7E1E186EC44B9337EE6737C4AD1C>]/Index[2788 15]/Info 2787 0 R/Length 52/Prev 467775/Root 2789 0 R/Size 2803/Type/XRef/W[1 2 1]>>stream vehicles or operating heavy machinery. relaxants and appears to be the safest. may have some toxicity in overdose and in combination with other substances.Carisoprodol presents the most significant concern, due particularly Carisoprodol painful musculoskeletal conditions.Carisoprodol, cyclobenzaprine and metaxalone are not found to be effective to meprobamate.In the head to head trial of cyclobenzaprine and carisoprodol, dry mouth

is thought to carry an important risk for abuse because of its metabolism

More absolute contraindications Pharmacist's Letter includes:. Skeletal muscle relaxants are commonly prescribed for the treatment of muscle spasms and discomfort. ��Y(R���"#�K���ѝk2����g�II\��/g’(�`a%[S�).� ���dpk����q��₍�4}�Lv 12 issues every year, with brief articles about new meds and hot topics; 300+ CE courses, including the popular CE-in-the-Letter; Quick reference drug comparison charts Muscle spasms can be caused by musculoskeletal conditions, such as back pain and neck pain, or neurological conditions associated with upper motor neuron lesions, such as multiple sclerosis.Both underlying causes can result in localized tenderness, significant pain, limitation of movement, and disability.. efficacious in the treatment of painful musculoskeletal disorders. These drugs relieve muscle spasms due to low back pain, neck pain, fibromyalgia, tension headaches. Studies Copyright © 2007-2020 eMedExpert.com. h�b```��|����XX��c� �1�Y�I�O��������6Z. Muscle relaxants treat both muscle spasm and spasticity. %PDF-1.5 %����