In these patients, very high olanzapine blood levels were reported after death.

If experienced, these tend to have a Severe expression 1. However, like other atypical antipsychotic drugs (quetiapine, clozapine), olanzapine causes paradoxically small pupils (due to peripheral alpha blockade) rather than the dilated pupils seen in this case. Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. This means that in the correct setting, the pupils measure less than 2mm or larger than 7mm. Available for Android and iOS devices. Altered Mental Status from Olanzapine Overdose Treated with Physostigmine.

"Product Information. His blood pressure was then well maintained at 130/80 as was his urine output.He was treated for aspiration pneumonia and once the plasma levels of olanzapine and venlafaxine had reached therapeutic levels, he was successfully extubated. Diarrhea 6.

Olanzapine overdose May produce drowsiness and anticholinergic delirium. In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal (ULN) in approximately 30% of patients who had normal baseline prolactin values. This was illustrated by commencing this patient on norepinephrine. ZyPREXA Relprevv (OLANZapine)." Why Are Dementia Patients Getting Risky Psychiatric Drugs? A High Prolactin Level 2. Constipation 4.

No specific antidote exists for olanzapine with the mainstay of management being general supportive and symptomatic measures. (2006). Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of olanzapine may occur that usually Check with your health care professional if any of the following side effects Post-Injection delirium/sedation syndrome, a collection of signs and symptoms consistent with olanzapine overdose has been reported following injections of the extended-release IM suspension. Cerner Multum, Inc. "UK Summary of Product Characteristics." Events occurred in less than 0.1% of injections and in approximately 2% of patients receiving injections for up to 46 months. If experienced, these tend to have a Severe expression. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Olanzapine is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.Olanzapine appears to have a greater association than some other Clinically significant alterations in lipids have been observed including serum triglyceride elevations greater than 500 mg/dL. The most commonly remembered cause of miosis is opiate use. Though the QT interval became more prolonged, it never rose above the upper limit of normal and no arrhythmias occurred on cardiac monitoring.Please check your email for instructions on resetting your password. Onset of events ranged from soon after injection to greater than 3 hours later.

A 37‐year‐old male suffering from severe obsessive compulsive disorder with psychotic features took an overdose of 700 mg of olanzapine and 9450 mg of venlafaxine. 3, pp. Dizziness 7.

319-325.

Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. O 04. Generalized Weakness 10. Symptoms may include coma, dilated pupils, respiratory depression and hypotension.