Ann Pharmacother 34 (2000): 32-436. J Allergy Clin Immunol 84 (1989): 26-3337. Paracetamol is contained in many medicines to treat pain, fever, symptoms of cold and flu, and sleep medicines. Due to limited clinical trial data, the frequency of these adverse events is not known (cannot be estimated from available data), but post-marketing experience indicates that adverse reactions to paracetamol are rare and serious reactions are very rare.Cutaneous hypersensitivity reactions including skin rashes, angioedema and Stevens Johnson syndrome/toxic epidermal necrolysis* There have been cases of bronchospasm with paracetamol, but these are more likely in asthmatics sensitive to aspirin or other NSAIDs.When the recommended paracetamol-caffeine dosing regimen is combined with dietary caffeine intake, the resulting higher dose of caffeine may increase the potential for caffeine-related adverse effects such as insomnia, restlessness, anxiety, irritability, headaches, gastrointestinal disturbances and palpitations.Liver damage is possible in adults who have taken 10 g or more of paracetamol. Wong V, Daly M, Boon A, Heatley V "Paracetamol and acute biliary pain with cholestasis."

Arch Intern Med 151 (1991): 1189-919. Hum Toxicol 7 (1988): 33-410. Ann Emerg Med 26 (1995): 49-5330. Some period pain is caused by underlying medical conditions like endometriosis or pelvic inflammatory disease. Koulouris Z, Tierney MG, Jones G "Metabolic acidosis and coma following a severe acetaminophen overdose." The CNS effects of overdose may be treated with intravenous sedatives.Treatment of overdose requires assessment of plasma paracetamol levels for antidote treatment, with signs and symptoms of caffeine toxicity being managed symptomatically.The combination of paracetamol and caffeine is a well established analgesic combination.Paracetamol is rapidly and almost completely absorbed from the gastro-intestinal tract.

Med J Aust 157 (1992): 382-516. Whitcomb DC, Block GD "Association of acetaminopphen hepatotoxicity with fasting and ethanol use."

N Engl J Med 331 (1994): 1311-28. We comply with the HONcode standard for trustworthy health information - Important information about Panadol. Guccione JL, Zemtsov A, Cobos E, Neldner KH "Acquired purpura fulminans induced by alcohol and acetaminophen - successful treatment with heparin and vitamin-k." Arch Dermatol 129 (1993): 1267-946. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Diarrhoea & Vomiting. Blood 109 (2007): 3608-944. Singer AJ, Carracio TR, Mofenson HC "The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction." Continue typing to refine. BMJ 306 (1993): 157-829. Nelson EB, Temple AR "Acetaminophen hepatotoxicity, fasting, and ethanol." Minton NA, Henry JA, Frankel RJ "Fatal paracetamol poisoning in an epileptic." • Child resistant PVC/Aluminium foil/polyethylene terephthalate blister packs in an outer cardboard carton Thomas RH, Munro DD "Fixed drug eruption due to paracetamol."

Symptoms may be limited to nausea or vomiting and may not reflect the severity of overdose or the risk of organ damage. Hartleb M "Do thyroid hormones promote hepatotoxicity to acetaminophen?" Am J Med 96 (1994): 3-915. Applies to acetaminophen: capsule, capsule liquid filled, elixir, liquid, powder, solution, suppository, suspension, syrup, tablet, tablet chewable, tablet disintegrating, tablet extended release Other dosage forms: 1. intravenous solution