Therapy with sulfonamides should be administered cautiously in patients with urinary obstruction or retention, since excessive drug accumulation may occur. Pyrimethamine-sulfadoxine. Select one or more newsletters to continue. It is estimated that 10% to 15% of all hospitalized patients treated with antibiotics will develop AAD? It has become familiar to millions through a diverse publishing program that includes scholarly works in all academic disciplines, bibles, music, school and college textbooks, business books, dictionaries and reference books, and academic journals. Applies to: Renal DysfunctionSulfonamides and their metabolites are eliminated by the kidney. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. Special sections include articles on antimicrobial Tell your health care provider if you are taking any other medicines, especially any of the following:This may not be a complete list of all interactions that may occur. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Clinical Infectious Diseases publishes clinically relevant articles on the pathogenesis, … Sulfonamide therapy should be stopped at once if a rash develops.Major Potential Hazard, Moderate plausibility.

Sulfadoxine/pyrimethamine, sold under the brand name Fansidar, is a combination medication used to treat malaria. of diseases caused by infectious agents. glass of water with each dose and throughout the day) and adequate urinary output (> 1.5 L/day) should be maintained during sulfonamide administration. Pyrimethamine selectively inhibits the plasmodial form of dihydrofolate reductase, reducing the production of folic acid required for nucleic acid synthesis in the malarial parasite (see Fig. Pyrimethamine/sulfadoxine is an antimalarial agent. Patients who are dehydrated (e.g., due to severe diarrhea or vomiting) may be at increased risk for the development of crystalluria and lithiasis and should be encouraged to consume additional amounts of liquid or given intravenous fluid.

Severe and sometimes fatal reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been associated with the use of pyrimethamine/sulfadoxine. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, … Published for the Infectious Diseases Society The aminoglycoside, macrolide, tetracycline, and sulfa classes of antibiotics provide antimicrobial coverage pertinent to many infectious diseases diagnosed in the emergency department (ED). However, the use of these agents may be considered in unusual situations in which the recommended agents cannot be administered (CIII). Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. All Rights Reserved. Antifungals, Antivirals, Antiparasitics/Antihelminths, Antimicrobials (All) Pyrimethamine is a folate antagonist. Applies to: Asthma, HIV Infection, AllergiesThe use of sulfonamides is associated with large increases in the risk of Stevens-Johnson syndrome, toxic epidermal necrolysis and other serious dermatologic reactions, although these phenomena are rare as a whole. Renal function tests and urinalysis should be performed weekly, especially during prolonged therapy (> 2 weeks).Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In malaria treatment it is only applied in combination with another folic acid antagonist such as sulfadoxine (Section 2.6.7).

It works by blocking the formation of folinic acid within the malaria organism, which kills the parasite.Contact your doctor or health care provider right away if any of these apply to you.Some medical conditions may interact with pyrimethamine/sulfadoxine. Available for Android and iOS devices. Renal function tests and urinalysis should be performed weekly or as often as indicated by the patient's status. The most common culprits are clindamycin, lincomycin, the aminopenicillins (amoxicillin, ampicillin), and the cephalosporins. Applies to: Dehydration, Diarrhea, VomitingCrystalluria can occur during sulfonamide therapy due to precipitation of the sulfonamide and/or its N4-acetyl metabolite in the urinary tract. Applies to: Liver DiseaseHepatotoxicity, including jaundice, diffuse hepatocellular necrosis, hypersensitivity hepatitis and hepatic failure, has rarely been reported in patients receiving sulfonamides. glass of water with each dose and throughout the day) and adequate urinary output (> 1.5 L/day) should be maintained during sulfonamide administration. JSTOR®, the JSTOR logo, JPASS®, Artstor®, Reveal Digital™ and ITHAKA® are registered trademarks of ITHAKA. 51.4). Patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency should be observed closely for signs of hemolytic anemia.

kgway. It contains sulfadoxine (a sulfonamide) and pyrimethamine (an antiprotozoal ). The sulfa agents are appropriate for many urinary and respiratory tract infections, and also have particular utility in some infections encountered primarily in patients with AIDS.