Save more with Subscribe & Save. , and , Sequential exposure of Malassezia pachydermatis to azoles: Enhanced or decreased activity?, In Vitro Antifungal Susceptibility of Malassezia pachydermatis Strains Isolated from Dogs with Chronic and Acute Otitis Externa, In dogs with end-stage otitis externa and concurrent otitis media, bacterial organisms can be isolated from the exudate in the lumen of the vertical ear canal and middle ear cavity as well as from the tissue from these sites. In patients with severe infections or with long-standing chronic otitis externa, you may need to add a systemic antimicrobial agent to clear the infection in the ear tissue as well as in the lumen of the ear canal. 4.2 out of 5 stars 671. , In vitro antifungal activity of topical and systemic antifungal drugs against alassezia species, They're also indicated in cases of allergic otitis externa. Topical otic preparations generally contain glucocorticoids, antibiotics, antifungals or some combination thereof in a vehicle base.

EXOTIC ANIMAL FORMULARY FOURTH EDITION James W. Carpenter, MS, DVM, Diplomate ACZM Professor, Zoological Medicine, Department of Clinical Sciences, College of Malassezia pachydermatis The advantage of topical therapy is that you can achieve 100 to 1,000 times the plasma level of the antimicrobial agent by administering it topically. Genotyping and antifungal susceptibility testing of multiple Otic yeast infections require topical therapy in addition to systemic therapy for resolution. Start with the chronicity of the otitis, the results of your otic examination, and your otic cytology results. isolates from otitis and dermatitis cases in pets: is it really worth the effort? No commercially available topical otic treatments are labeled for use with a non-intact tympanic membrane, but most of them have been used to treat otic infections in dogs with otitis media. Dermatologic Solution TRESADERM® (thiabendazole, dexamethasone, neomycin sulfate solution) contains the following active ingredients per mL: 40 mg thiabendazole, 1 mg dexamethasone, 3.2 mg neomycin (from neomycin sulfate).
More Buying Choices $9.45 (9 new offers) Warn clients to watch for neurological signs of ototoxicity while administering topical medications when the tympanic membrane is not intact. They're usually used in combination with other agents but may be beneficial when used alone in allergic cases of otitis and some ceruminous otitis cases. Topical therapy is almost always a staple of treatment, and systemic antimicrobials may be necessary as well. Glucocorticoids are therefore beneficial in decreasing the pain, pruritus, stenosis and edema associated with otitis. Dermatologic Solution TRESADERM®(thiabendazole, dexamethasone, neomycin sulfate solution) contains the following active ingredients per mL: 40 mg thiabendazole, 1 mg dexamethasone, 3.2 mg neomycin (from neomycin sulfate). Tresaderm is used topically on the skin or in the ears depending on the type of infection being treated. Inactive ingredients: glycerin, propylene glycol, purified water, hypophosphorous acid, calcium hypophosphite; about 8.5% ethyl alcohol and about 0.5% benzyl alcohol. Indications for systemic antifungal agents are similar to those for bacterial infections. Malassezia pachydermatis Use systemic products in patients with yeast otitis media or severe yeast otitis externa and for owners who cannot administer topical therapy. So most experts agree that systemic antibiotics-based on culture and susceptibility testing-are indicated in patients with: It's important to select a systemic antimicrobial agent based on culture and susceptibility testing from the external ear (for otitis externa) and middle ear (for otitis media), but go ahead and initiate therapy based on cytologic results while you're waiting on culture and susceptibility results. Remember, culture and sensitivity testing results indicate the plasma level of an antimicrobial agent. With that note, let's look at topical agents one at a time.
Choose first-line topical otic medications for cases of acute or occasional otitis externa, reserving second-line otic medications, such as those containing fluoroquinolones, for cases of bacterial otitis due to Systemic antimicrobial therapy for infectious otitis externa and otitis media is controversial. Antifungal agent susceptibilities and interpretation of In addition, they're effective in decreasing sebaceous and apocrine secretions. In Vitro Examples include Cort/Astrin Solution (Vedco) and Synotic (Zoetis).