The optimum times for making the first and subsequent transaminase measurements are not known. VOLTAREN GEL should be gently massaged into the skin ensuring application to the entire affected hand, wrist, or elbow. Unlike other topical pain relief gel products that simply heat or cool the surface of the skin, Voltaren treats the pain instead of just masking it. wikiHow's Voltaren Gel is a topical ointment that's used to help treat pain that comes along with osteoarthritis and joint problems, such as stiffness, aches, and swelling. This is not a complete list of side effects and others may occur. Exercise caution when prescribing VOLTAREN GEL with concomitant drugs that are known to be potentially NSAIDs, including VOLTAREN GEL, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which may contribute to the increased incidence of CV events. Diclofenac topical gel (applied to the skin) is used to relieve pain associated with recent muscle or joint injuries such as sprains, strains, or sports injuries. Follow your doctor's orders or the directions on the label. The entire foot includes the sole, top of the foot, and the toes. In animal reproduction studies, no evidence of teratogenicity was observed in mice, rats, or rabbits given diclofenac during the period of organogenesis at doses up to approximately 5, 5, and 10 times, respectively, the maximum recommended topical dose of VOLTAREN GEL, despite the presence of maternal and fetal toxicity at these doses [see There are no studies on the effects of VOLTAREN GEL during labor or delivery. It may not be safe to breastfeed while using this medicine. Duration of exposure ranged from 8 to 12 weeks for the placebo-controlled studies, and up to 12 months for the open-label safety trial.Non-serious adverse reactions that were reported during the short-term placebocontrolled studies comparing VOLTAREN GEL and placebo (vehicle gel) over study periods of 8 to 12 weeks (16 g per day), were application site reactions. What joints are most often affected by osteoarthritis? Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).You should not use Voltaren Gel if you are allergic to diclofenac (Voltaren, To make sure Voltaren Gel is safe for you, tell your doctor or pharmacist if you have:Diclofenac can affect ovulation and it may be harder to get pregnant while you are using this medicine. Store the dosing card with your VOLTAREN GEL.Manufactured by: GSK Consumer Healthcare, Warren, NJ 07059. The following information includes only the average doses of this medicine. with your health care provider. Revised May2016Your healthcare provider has prescribed VOLTAREN® GEL to Of these, 513 patients received VOLTAREN GEL for osteoarthritis of the knee and 400 were treated for osteoarthritis of the hand. "Just wanted to know how long after applying gel I should leave it before showering. The amount of diclofenac sodium that is systemically absorbed from VOLTAREN GEL is on average 6% of the systemic exposure from an oral form of diclofenac sodium.The average peak plasma concentration with recommended use of VOLTAREN GEL (4 x 4 g per day applied to 1 knee) is 158 times lower than with the oral treatment.The pharmacokinetics of VOLTAREN GEL has been tested under conditions of moderate heat (application of a heat patch for 15 minutes prior to gel application) and of moderate exercise (first gel application followed by a 20-minute When NSAIDs were administered with aspirin, the protein binding of NSAIDs were reduced, although the clearance of free NSAID was not altered. effective if used on your spine, hips, or shoulders.This Medication Guide and Instructions for Use have been In animal studies, NSAIDS, including diclofenac, inhibit prostaglandin synthesis, cause delayed Reproductive and developmental studies in animals demonstrated that diclofenac sodium administration during organogenesis did not produce teratogenicity despite the induction of maternal toxicity and fetal toxicity in mice at oral doses up to 20 mg/kg/day (approximately 5 times the maximum recommended human dose (MRHD) of VOLTAREN GEL based on bioavailability and body surface area (BSA) comparison), and in rats and rabbits at oral doses up to 10 mg/kg/day (approximately 5 and 10 times the MRHD based on bioavailability and BSA comparison).In a study in which pregnant rats were orally administered 2 or 4 mg/kg diclofenac (approximately 1 and 2 times the MRHD based on bioavailability and BSA comparison) from Gestation Day 15 through Lactation Day 21, significant maternal toxicity (Based on available data, diclofenac may be present in human milk. This article was co-authored by our trained team of editors and researchers who validated it for accuracy and comprehensiveness. Skip the missed dose if it is almost time for your next scheduled dose. The clinical significance of this interaction is not known. VOLTAREN GEL was administered at a dose of 4 g, 4 times daily, on 1 knee (16 g per day).