Generic Name: Bupropion HCL (byoo-PROE-pee-on) Drug Class: Antidepressant, Miscellaneous Table of Contents Overview How to Take It Side Effects Warnings & Some people, according to the advisory, have become depressed or have had their depression worsen, have had thoughts about suicide or dying, or have attempted suicide.In a large-scale study of programs where bupropion was used for smoking cessation or treatment of depression, no withdrawal symptoms were observed.Bupropion is considered moderately dangerous in overdose.In the majority of childhood exploratory ingestions involving one or two tablets, children show no apparent symptoms.Caution should be observed when combining bupropion with a Bupropion inhibits the reuptake of dopamine through the human Bupropion causes antidepressant activity as it selectively inhibits dopamine and norepinephrine re-uptake.The metabolism of bupropion is highly variable: the effective doses of bupropion received by persons who ingest the same amount of the drug may differ by as much as 5.5 times (with a There have been reported cases of false-positive urine amphetamine tests in persons taking bupropion.In 2016, three new major metabolites of bupropion, all formed exclusively by It is synthesized in two chemical steps starting from 3'-chloro-Bupropion was invented by Nariman Mehta of Burroughs Wellcome (now In France, marketing authorization was granted for Zyban on 3 August 2001, with a maximum daily dose of 300 mg;On 11 October 2007, two providers of consumer information on nutritional products and supplements, In April 2008, the FDA approved a formulation of bupropion as a hydrobromide salt instead of a hydrochloride salt, to be sold under the name Aplenzin by In 2012, the U.S. Justice Department announced that GlaxoSmithKline had agreed to plead guilty and pay a $3-billion fine, in part for promoting the unapproved use of Wellbutrin for weight loss and sexual dysfunction.According to the US government classification of psychiatric medications, bupropion is "non-abusable".It is sold under many trade names worldwide and in combinations with It is sold under many trade names worldwide including Aplenzin, Budeprion SR, Bup, Bupredol, Buproban, Bupropion GSK, BuPROPion HCL SR Watson, Bupropion Hydrochloride Anchen, Bupropion Hydrochloride Apotex, BuPROPion Hydrochloride Cadista, Bupropion Hydrochloride Mylan, Bupropion Hydrochloride Sandoz, buPROPion Hydrochloride SR actavis, Bupropion Hydrochloride Sun Pharma, buPROPion Hydrochloride Torrent Pharma, Bupropion Hydrochloride Wockhardt, buPROPion Hydrochloride XL actavis, BuPROPion Hydrochloride XL Watson, Bupropion SR Sanis Health, Bupropionhydrochlorid HEXAL, Bupropionhydrochloride GSK, Buprotrin, Butrin, Buxon, Carmubine, Depnox-SR, Elontril, Elontril XL, Forfivo XL, Funnix, Global buPROPion HCL, Le Fu Ting, Odranal, PMS-Bupropion SR, Prewell, Quomem, ratio-Bupropion SR, Sandoz Bupropion SR, Voxra, Wellbutrin, Wellbutrin Retard, Wellbutrin SR, Wellbutrin XL, Wellbutrin XR, Yue Ting, Zetron, Zyban, Zyban LP, Zybex SR, ZyGenerics Bupropion Hydrochloride XL, and Zyntabac.Substituted amphetamine medication mainly for depression and smoking cessationInChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3This diagram shows the synthesis of bupropion via 3'-chloro-propiophenone. Breaking or chewing an XR tablet increases the risk of an overdose, and possibly seizures.Always follow the doctor’s instructions exactly to avoid any risks.It can take weeks or months for Wellbutrin to relieve the symptoms of depression. Pharmacology, adverse reactions, warnings and side effects. It is best to use it without nicotine replacement therapy (NRT).In the first days after starting treatment, the person may experience agitation, restlessness, and Wellbutrin is not suitable for people who are susceptible to seizures, as it can lower the seizure threshold, making it easier for a seizure to occur.Anyone who has a seizure while using Wellbutrin should stop taking the medication and inform their doctor.The most common side effects, which affect more than 1 in 10 people, include:Psychological effects may occur, such as feeling restless or hostile or experiencing delusions or a sense of depersonalization.A risk of suicidal thinking and behavior has been linked to the use of several antidepressants, but it is not clear that the drugs increase the risk. All rights reserved. Wellbutrin, or bupropion, is a drug that is mainly used to treat depression. The Food and Drug Administration (FDA) warns that people who are taking one of these drugs to stop smoking must not take the same drug under another name to treat depression.If any of the following symptoms occur, medical assistance should be sought immediately: a skin rash, itching, trouble breathing, chest pain, or swelling of the face, tongue, or throat.Anyone experiencing any of the following reactions should seek medical advice:© 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. SNRIs are also sometimes used to treat other conditions, such as anxiety disorders and long-term (chronic) pain, especially nerve pain. Selective serotonin reuptake inhibitor is a class of medications used to treat anxiety, depression, or other mental disorders. It can also be used to help people stop smoking.Other names include Aplenzin, Budeprion, Forfivo, Chantix, and Zyban.This article will look at how Wellbutrin is used, how it works, its side effects, and any important warnings.It was first approved for clinical use in the United States (U.S.) in 1985. A course of treatment normally takes 7 to 12 weeks, but by day 10, the individual has often stopped smoking.A person who wants to stop smoking may be prescribed a 150-mg tablet of Zyban, or possibly Chantix, twice a day. Bupropion (Aplenzin, Wellbutrin XL) is also used to treat seasonal affective disorder (SAD; episodes of depression that occur at the same time each year [usually in the fall and winter but rarely may occur in the spring or summer months]). Serotonin and norepinephrine reuptake inhibitors (SNRIs) are a class of medications that are effective in treating depression.