If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.This medicine is not recommended for use in patients with a known allergy to Divalproex, or any other inactive ingredients present along with the formulation.This medicine is not recommended for use in patients with active and/or severe liver diseases.This medicine is not recommended for use in patients with urea cycle disorders (high ammonium levels in the blood) or family history of urea cycle disorder.This medicine is not recommended for use in patients and children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).This medicine is not recommended for use in patients suffering from porphyria, a disorder where there is an over-accumulation of porphyrin in the body.This medicine is not recommended for use in pregnant women except in life-threatening conditions. For non-prescription products, read the label or package ingredients carefully.Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of valproic acid in children. Proper use of Depakote DR. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If it is almost the time for your next dose, skip the missed dose.
Valproate can impair cognitive development with prenatal exposure and produce major congenital malformations, particularly neural tube defects (eg, spina bifida). Perform POLG mutation screening as clinically indicated. Cases have occurred shortly after initiation as well as several years after use. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.This medicine should be used with caution in patients with depression and suicidal thoughts. Life-threatening pancreatitis has been reported in both children and adults receiving valproate. Perform POLG mutation screening as clinically indicated. Make sure you tell your doctor if you have any other medical problems, especially:This medicine comes with a Medication Guide or patient information leaflet.
Ask your doctor if you have any questions.The dose of this medicine will be different for different patients. Do not take in larger or smaller quantities than recommended. Keep from freezing.Do not keep outdated medicine or medicine no longer needed.Ask your healthcare professional how you should dispose of any medicine you do not use.Using this medicine while you are pregnant (especially during the first 3 months of pregnancy) can harm your unborn baby and cause serious unwanted effects (eg, brain or facial problems, heart or blood vessel problems, arm or leg problems, or intelligence or mental problems).
These may be symptoms of a serious condition called hyperammonemic encephalopathy.Valproic acid may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Take this medicine at the same time regularly.
The results of some tests may be affected by this medicine.This medicine will add to the effects of alcohol and other CNS depressants (medicines that cause drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures (eg, barbiturates), muscle relaxants, or anesthetics, including some dental anesthetics.
When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below.