Dexamethasone hiccups treatment entocort


The aims of this study were to investigate the feasibility of methylprednisolone rotation as treatment and to confirm the male predominance among those with cancer who experienced DIH during chemotherapy.





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The treatment maneuver described in this study has the potential to improve quality of life in cancer patients undergoing chemotherapy.Dexamethasone is an essential agent for preventing chemotherapy‐induced emesis. Medications have been implicated as a cause of hiccups. Persons with cancer who experienced hiccups during chemotherapy treatment and who were receiving treatment with dexamethasone were presumed to have DIH. Hiccups are a common, usually harmless, and self‐limiting disorder. Numerous factors such as cancer invasion and chemicals that irritate nerves belonging to the afferent limb can provoke hiccups. Of these 34 patients, 25 (73.5%) had recurrence of hiccups after dexamethasone re‐administration. Although discontinuation of therapy may be sufficient, patients occasionally may require pharmacologic intervention. The incidence of corticosteroid‐associated hiccups is unknown. Because he was responding to dexamethasone, the decision was made to continue therapy and to relieve his hiccups with metoclopramide.Low dose oral metoclopramide allowed the patient to continue therapy without a recurrence of the hiccups.Dexamethasone administration can result in intractable hiccups that persist for the duration of therapy. We also identified male predominance of DIH. Our analysis focused on determining whether methylprednisolone rotation could resolve DIH and maintain antiemetic effectiveness in patients undergoing chemotherapy.

Low dose oral metoclopramide may prevent hiccups in patients in whom the discontinuation of dexamethasone therapy is not appropriate. Persons with cancer who experienced hiccups during chemotherapy treatment …