Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. Results Twenty-six studies were included that contained more than 3 million participants and 170,000 pancreatic cancer patients. Search for other works by this author on: Presumably, the behaviors would be less likely to stop at the same time as statin medication discontinuation, so a comparison of continuing statin users with those who stopped statin therapy should have been less susceptible to confounding by behavior change.We identified 32,494 patients with gallstone disease (18,201 inpatients and 14,293 outpatients) and 324,925 population controls. Statins' known benefits in preventing cardiovascular disease, along with years of strong evidence that these agents are relatively safe, have led researchers to explore whether statins have the potential to prevent cancer. In current users, the adjusted odds ratios associating statin use with the occurrence of gallstone disease were 1.17 (95% confidence interval (CI): 1.06, 1.30) for those who had 1–4 prescriptions, 0.89 (95% CI: 0.80, 0.97) for those who had 5–19 prescriptions, and 0.76 (95% CI: 0.69, 0.84) for those who had ≥20 total prescriptions. Search for other works by this author on: Oral Glucocorticoids and Incident Treatment of Diabetes Mellitus, Hypertension, and Venous Thromboembolism in Children Multicenter Italian Study on Epidemiology of CholelithiasisStrong association between gallstones and cardiovascular diseaseThe prevalence and risk factors for gallstone diseaseEffects of simvastatin on hepatic cholesterol metabolism, bile lithogenicity and bile acid hydrophobicity in patients with gallstonesInfluence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterolSimvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bileThe effects of the 3-hydroxy, 3-methylglutaryl coenzyme A reductase inhibitor pravastatin on bile composition and nucleation of cholesterol crystals in cholesterol gallstone diseaseThe use of simvastatin for the prevention of gallstones in the lithogenic prairie dog modelLovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogsThe national patient registry. Fourth, because the comparison of statin users with nonusers might be confounded by statin indications also associated with gallstone disease (e.g., obesity, hyperlipidemia, exercise, and diet), we compared statin users with a total of 5–19 and ≥20 prescriptions with a reference category of users with 1–4 prescriptions. The use of other lipid-lowering drugs showed no similar association.The prevalence of gallstone disease in the Western world ranges from 6% to 50%, increasing with age and varying with geographic region (In the liver, 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) inhibit cholesterol biosynthesis, and thus may prevent gallstone formation, gallstone recurrence, subsequent complications, and cholecystectomy. This is still being studied. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.The increase generally occurs when blood sugar levels are already higher than normal and fall in the prediabetes or diabetes range when you begin taking a statin.Statins prevent heart attacks in people with diabetes, so the relevance of the mild increase in sugar values with statins observed in some people is unclear. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.