2014 Apr;101(4):e23. Methotrexate is generally administered as a single dose.
You will need to have blood tests to monitor the level of pregnancy hormone in your blood. If a 15% drop was not seen, the medical treatment was deemed refractory and the patients were referred for surgical treatment.Participants in the "two-dose protocol" group received intramuscular methotrexate twice at dose of 50 mg/m2 on day 0 and 4.
Unable to load your collection due to an error Currently, there are three methotrexate protocols for the treatment of an ectopic pregnancy, "multi-dose", "single-dose", or "two-dose". Based on your blood test results, your doctor will tell you if you need another injection of methotrexate. Thirty-one patients were eligible for this outpatient treatment protocol. It can be used as a way (other than surgery) to treat a pregnancy that’s implanted outside the uterus (ectopic pregnancy). Medical management with systemic methotrexate administration avoids the inherent morbidity of anesthesia and surgery is cost-effective, and also offers success rates comparable to surgical management, with no loss in future potential fertility.However, although medical management using methotrexate is used commonly, there is no solid consensus regarding dose protocol. One patient withdrew from follow-up, leaving 30 patients (96.8%) in the study group. The methotrexate will stop the pregnancy and the level of pregnancy hormone in your blood should decrease over 2 to 4 days. methotrexate for ectopic pregnancy. If you have questions, talk with your doctor or appropriate healthcare provider. This serious condition can lead to complications, such as internal bleeding, If a woman who is taking methotrexate suspects that she is pregnant, she should take a pregnancy test as soon as possible. Measures of current trends in the management of ectopic pregnancy in the United States from 2002 to 2007 indicated that the percentage of patients treated with methotrexate increased from 11.1% to 35.1%, whereas surgical management decreased from approximately 90% to 65%. Dose of methotrexate is calculated based on estimated body surface area.There are a number of methods for estimation of body surface area, but this calculator used the DuBois method.
It's very important that the diagnosis of ectopic pregnancy is certain before receiving this treatment. Precautions Males should not take methotrexate when trying for a baby.People can avoid unplanned pregnancies by using an effective form of Doctors may use methotrexate injections to treat an ectopic pregnancy because they interrupt the growth and division of a fertilized egg.Specifically, methotrexate interrupts the supply of a hormone called human chorionic gonadotropin (hCG) to the fertilized egg. Review adverse effects as below; Abdominal Pain may occur 2-3 days after Methotrexate. Use Contraception and avoid pregnancy until at least 1-3 ovulatory cycles from bHCG undectable; Monitor patients closely on Methotrexate protocol. Unable to load your delegates due to an error These rates are similar to A third dose of methotrexate was given on day 7 if β-hCG levels did not fall 15% between day 4 and 7 after two-dosing. If a 15% drop was not seen, the medical treatment was deemed refractory and the patients were referred for surgical treatment.Participants in both groups were considered a treatment success if β-hCG levels resolved to <5 mIU/mL without surgical intervention. Despite advances in early diagnosis and treatment, ectopic pregnancy (EP) is the most common cause of maternal mortality during the first trimester in the United States.