Salmonella typhi was isolated from the initial cultures of blood samples from 64 patients.
All Salmonella isolates were susceptible to both antibiotics. To study the pharmacokinetics of ceftriaxone in acute typhoid fever, 10 febrile Nepalese adolescents and young adults with blood culture-positive illness were treated with 3 g of ceftriaxone (intravenous infusion for 30 min) daily for 3 days. When the two patients with medical complications causing persistent fever and the patient who was febrile during therapy were excluded from the calculations, the mean period of defervescence was 4 days. The efficacy and safety of ceftriaxone in the treatment of bacteremic typhoid fever was studied in 14 patients. The advantages of its use include rapid clinical response, short course of treatment, and lack of serious adverse drug reactions. 1991.Rev Infect Dis. Please enable it to take advantage of the complete set of features! Applies to the following strengths: 250 mg; 500 mg; 1 g; 2 g; 10 g; 1 g/50 mL-iso-osmotic dextrose; 2 g/50 mL-iso-osmotic dextrose1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 to 2 g IV or IM once a day (or in equally divided doses twice a day)1 g IV as a single dose 30 to 120 minutes before surgeryAHA and IDSA Recommendations: 1 g IV or IM as a single dose 30 to 60 minutes before dental procedureAmerican Academy of Neurology (AAN) and IDSA Recommendations: 2 g IV once a dayAmerican Academy of Neurology (AAN) and IDSA Recommendations: 2 g IV once a dayAmerican Academy of Neurology (AAN) and IDSA Recommendations: 2 g IV once a dayUS CDC, National Institutes of Health (NIH), and HIV Medicine Association of the IDSA (HIVMA/IDSA) Recommendations for HIV-infected Patients: 2 g IV or IM once a day for 10 to 14 daysUS CDC, NIH, and HIVMA/IDSA Recommendations for HIV-infected Patients: 1 g IV every 24 hoursUS CDC, NIH, and HIVMA/IDSA Recommendations for HIV-infected Patients: 1 g IV every 24 hoursUS CDC, NIH, and HIVMA/IDSA Recommendations for HIV-infected Patients: 1 g IV or IM once a day for 10 to 14 days1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)1 month or older: 50 to 75 mg/kg/day IV or IM in divided doses every 12 hours1 month or older: 50 to 75 mg/kg/day IV or IM in divided doses every 12 hours1 month or older: 50 to 75 mg/kg/day IV or IM in divided doses every 12 hoursAAN and IDSA Recommendations: 50 to 75 mg/kg IV once a dayUS CDC, NIH, and HIVMA/IDSA Recommendations for HIV-infected Adolescents: 1 g IV every 24 hoursUS CDC, NIH, and HIVMA/IDSA Recommendations for HIV-infected Adolescents: 1 g IV every 24 hoursRenal dysfunction alone: No adjustment recommended.Liver dysfunction alone: No adjustment recommended.Elderly patients: No adjustment needed for doses up to 2 g/day, as long as there is no severe renal and liver dysfunction.This drug is contraindicated in premature neonates up to postmenstrual age of 41 weeks (gestational age + chronological age); this drug is not recommended for use in hyperbilirubinemic neonates.Renal failure: No adjustment normally needed when standard doses are used.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

1993 Nov;37(11):2418-21. doi: 10.1128/aac.37.11.2418.Antimicrob Agents Chemother.


Could Antibiotics Make Breast Milk Less Healthy for Babies? In a prospective, randomized, open study ceftriaxone was compared with chloramphenicol for treatment of 59 children who had bacteriologically confirmed acute typhoid fever. When the two patients with medical complications causing persistent fever and the patient who was febrile during therapy were excluded … Select one or more newsletters to continue. The efficacy and safety of ceftriaxone in the treatment of bacteremic typhoid fever was studied in 14 patients. 2001 Dec;32(4):869-71.Clin Microbiol Rev. The 14 patients treated with ceftriaxone included 13 patients who were considered cured, although 1 was a convalescent carrier, and one patient who was a treatment failure.

Kinetic parameters including …