Dosing Information of Doxorubicin for Dogs and Cats; Medication should never be administered without first consulting your veterinarian. Doxorubicin is one of the 3 primary cancer drugs used in the Madison Wisconsin Protocol – but this drug can also be used alone in cases where patients don’t want to undertake the full Madison Wisconsin Protocol.. Unfortunately, most forms of feline lymphoma do not have the same response rates and remission times as canine lymphoma. The role of adjuvant chemotherapy after surgery for high-grade STS in dogs is yet to be determined, but as with any high-grade tumor with high metastatic rates, it should be considered.Doxorubicin is considered in the treatment of epithelial tumors such as mammary gland carcinoma. The treatment of choice for these types of tumors is always to control and diminish the amount of local disease. < 30 mg/m 2 or < 1 mg/kg for dogs weighing less than 15 kg.

A complete blood cell count with differentials should be performed 7 to 10 days after doxorubicin administration to monitor for white blood cell (specifically neutrophil) nadirs. This is especially recommended for breeds that are known to be prone to dilated cardiomyopathy Dexrazoxane is available in 250 and 500 mg sterile vials and is reconstituted with sodium lactate to a concentration of 10 mg/mL.Doxorubicin must always be administered through a clean, “one stick” intravenous catheter. Adverse effects can include acute vomiting, nausea, hives, blood pressure changes, and arrhythmias and are attributed to an anaphylactic response and a release of histamine.
However, DMSO is recommended by many oncologists in the event of an extravasation for the following reasonsDoxorubicin has the potential to cause some of the most severe delayed adverse effects of any drug in veterinary oncology. Pulmonary metastases are found on presurgical radiographs in approximately 10% of patients, but because lesions must be 4 to 6 mm in diameter to be visible on radiographs, it is thought that most patients have micrometastases at the time of surgery. If administered to cats, the dose should be 20 to 30 mg/m2 every three to four weeks. Doxorubicin is a drug that is designed to help address cancer cases in dogs. It mostly affects the hair around the muzzle and eyes, but severe cases of hair loss can occur Although doxorubicin poses significant risks in administration and toxicity, it is one of the most effective chemotherapeutic agents in veterinary medicine. Vomiting and/or diarrhea can cause translocation of bacteria, and if a patient’s immune response is compromised, sepsis may occur.Prophylactic antibiotics may be considered after a patient’s first dose of doxorubicin. Doxorubicin is diluted with sterile 0.9% sodium chloride or 5% dextrose solution; the dilution ratio may vary by hospital. The vein being used should be intact and should not have been used within the 24 to 48 hours before doxorubicin administration. Hundreds of published studies have since investigated its use. A veterinary technician’s role in the oncology world is not only to have excellent technical skills but also to also be warm and compassionate, be a patient advocate, and make connections with and educate clients. Vomiting, nausea, inappetence, and diarrhea are among the gastrointestinal side effects associated with doxorubicin administration. In addition, in the face of a chemotherapeutic spill or extravasation, it is necessary to know and act on the immediate response protocol.Doxorubicin is one of the most dangerous chemotherapeutics used in veterinary oncology. The median dosage of first doxorubicin was 30 mg/m 2 (range, 17.5–30 mg/m 2); 11 dogs weighed < 15 kg and treatment initiated at 1 mg/kg. It has potential antagonistic properties against 3 broad categories of tumors: round cell tumors, mesenchymal tumors, and epithelial tumors.

With her passion for helping animals and support from her coworkers, she achieved her Veterinary Technician Specialist certification in oncology in 2014.

Mammary gland tumors are one of the most common neoplasms in sexually intact female dogs, but the incidence rate in the United States is lower than many other countries, likely due to our early ovariohysterectomy practices.Studies have yet to show a clear survival or disease-free benefit from incorporating doxorubicin chemotherapy in the treatment of patients with large or multiple high-grade tumors with lymph node or pulmonary metastases. These tumors can be cured with aggressive surgery with or without radiation therapy.