Documentation of previous spirometry, smoking history and functional capacity is important in assessment of patients with AECOPD. Its mechanism of action is not fully known, although animal studies suggest that the bronchodilation involves the inhibition of two phosphodiesterase enzymes (PDE III and PDE IV) while the suppressive effects are probably due to diff…

Price noted that, in people with COPD at high risk of exacerbation, no benefit comes from the addition of low-dose theophylline, but a study in patients with frequent exacerbations who are being admitted to hospital might be warranted. Theophylline is a widely available medication which may further improve lung function and exercise performance. Long-term macrolide therapy and phosphodiesterase type 4 inhibitors may be options for some patients with recurrent exacerbations, but use of these agents can be cost prohibitive, or cannot be tolerated by all patients. Reduced activity of histone deacetylases (HDAC) contributes to enhanced inflammation in stable COPD. It was hypothesised that HDAC activity is further reduced during ECOPD and that theophylline… Inhaled therapy with long-acting bronchodilators, with or without inhaled glucocorticoids, can help prevent further exacerbations, but some patients continue to experience them despite optimal inhaled medical therapy. However, at clinically effective blood concentrations of around 10–20 mg/L, theophylline is frequently associated with adverse effects, such as nausea and other gastrointestinal disturbances, cardiac arrhythmias, and CNS excitation, leading to a narrow therapeutic window.

Reduced activity of histone deacetylases (HDAC) contributes to enhanced inflammation in stable COPD. The exacerbations of copd path for the chronic obstructive pulmonary disease pathway. Registration is free.Please login or register first to view this content.

Copyright Failure of Low-Dose Theophylline to Prevent Exacerbations in Patients With COPD. However, at clinically effective blood concentrations of around 10–20 mg/L, theophylline is frequently associated with adverse effects, such as nausea and other gastrointestinal disturbances, cardiac arrhythmias, and CNS excitation, leading to a narrow therapeutic window.

Our website uses cookies to enhance your experience. There were 3420 exacerbations of COPD symptoms during the year-long study. Exacerbation rates for participants who received Serious adverse events in patients in both groups included gastrointestinal (2.7% vs 1.3%) and cardiac (2.4% vs 3.4%) as well as nausea (10.9% vs 7.9%) and headaches (9.0% vs 7.9%), but the differences were not significant.The researchers noted the clinical relevance of this finding, suggesting, “The findings do not support the use of low-dose theophylline as adjunctive therapy to inhaled corticosteroids for the prevention of COPD exacerbations.”Please login or register first to view this content.Copyright © 2020 Haymarket Media, Inc. All Rights ReservedYou’ve viewed {{metering-count}} of {{metering-total}} articles this month.

Its non-bronchodilator effects suppress the response of the airways to stimuli. Close more info about Theophylline Adjunct Therapy Fails to Reduce COPD Exacerbations Background: Chronic obstructive pulmonary disease (COPD) is characterised by an abnormal inflammatory response mainly to cigarette smoke that flares up during exacerbations of the disease (ECOPD).

Results.

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In patients with COPD, even high doses of inhaled corticosteroids can fail to suppress airway inflammation.

Exacerbation rates for participants who received inhaled corticosteroids only and for those who received low-dose theophylline as adjunct therapy