Pre‐packed medication containing tolterodine or oxybutynin was issued at recruitment and at 4 weeks.

Leung, MBChB, MRCOG, FRANZCOG, FHKAM(O&G), Medical Officer.S.K.


As the motor supply to the detrusor muscle depends on the cholinergic pelvic nerve, antimuscarinic drugs would seem to be useful candidates for treating this condition.



University of Arkansas, Fayetteville.

Tell your doctor about all medications you use.










Overdose symptoms may include extreme drowsiness, confusion, hallucinations, very dry mouth, dilated pupils, pale skin, vomiting, or fainting.









Most of the patients were married housewives.

Despite the improvement in urinary frequency and possibly urgency (from the urinary diary) with treatment, there was no difference in incontinence episodes or pad use with medication. Follow the directions on your prescription label.Do not give this medication to a child younger than 4 years old.



Call your doctor for medical advice about side effects.

Improvements in urodynamic function can be detected after two weeks of treatment. This result is consistent with those observed earlier [The type of drug used had no effect on changes in the present voiding diary variables; this was also noted by others [Contrary to our hypothesis, in the present patients we were unable to show a higher compliance or lower withdrawal rate with the bladder‐selective tolterodine than with the standard first‐line drug, oxybutynin.

Take exactly as prescribed by your doctor.

Dry mouth was reported by significantly fewer patients on tolterodine, compared with oxybutynin (35% vs 63%; P = 0.001) and withdrawals due to adverse events were lower in the tolterodine group than with those treated with oxybutynin (10% vs 16%).

Tolterodine was clinically more effective than oxybutynin after 10 weeks of treatment. The overall drug compliance rate and withdrawal rate in the two treatment groups were compared.



Department of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongDepartment of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongCentre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, The Chinese University of Hong Kong, andDepartment of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongDepartment of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongDepartment of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongCentre for Clinical Trials and Epidemiological Research, Prince of Wales Hospital, The Chinese University of Hong Kong, andDepartment of Obstetrics & Gynaecology, Queen Elizabeth Hospital, Shatin, New Territories, Hong KongUse the link below to share a full-text version of this article with your friends and colleagues.



Severity was assessed subjectively using VAS, which were constructed following Frazer The severity was objectively assessed at baseline, 4 and 10 weeks using a voiding diary, and at baseline and 10 weeks using the urinary pad test. Select one or more newsletters to continue. The Periactin brand name has been discontinued in the U.S. Liu, MBBS, MRCOG, FHKAM(O&G), Medical Officer.K.H. Do not take in larger or smaller amounts or for longer than recommended. This includes prescription, over-the-counter, vitamin, and herbal products.



Chung, MBBS, FRACOG, FHKAM(O&G), MD, Chairman. The study period ended 2 weeks after stopping medical treatment, with a visit or telephone interview to assess the occurrence of late adverse events.The primary outcome measure was the tolerability of medical treatment. Recent literature strongly supports the efficacy and safety of tolterodine ER in carefully selected older men with OAB symptoms.



Each agent had comparable efficacy for improving urinary symptoms.







Assuming that 70% of patients on oxybutynin and 40% on tolterodine would experience deteriorating dry mouth symptoms that would cause noncompliance or withdrawal from medical treatment , the minimum sample size in each group was estimated to be 42, assuming a … Yip, MBChB, MRCOG, FHKAM(O&G), Associate Professor.C.

Non‐pharmacological treatment, e.g.



behavioural therapy, electrical stimulation, phenol injections and surgery, have been tried but with limited success.

Cheon, MBChB, MRCOG, FHKAM(O&G), Senior Medical Officer.Y.S.