The metabolic rate is decreased in patients with severe liver dysfunction resulting in a doubling of the area under the plasma concentration-time curve of esomeprazole. Studies evaluating concomitant administration of esomeprazole and either naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic interactions during short-term studies.Esomeprazole is metabolised by CYP2C19 and CYP3A4. The patients were treated for four weeks. Continue typing to refine. However, side effects such as dizziness and blurred vision may uncommonly or rarely occur (see section 4). Start typing to retrieve search suggestions. Peak concentrations of Nexium occur within one to four hours of an oral dose. But it only dealt with some of my symptoms and did not address the underlying cause, which in my case was diet and lifestyle. Severe Interactions. It is unknown whether esomeprazole/metabolites are excreted in human milk. This information is intended for use by health professionalsEach gastro-resistant tablet contains 20 mg esomeprazole (as magnesium trihydrate)Each gastro-resistant tablet contains 28 mg sucrose.A light pink, oblong, biconvex, film-coated, gastro-resistant tablet of 14 mm x 7 mm engraved with '20 mG' on one side and 'A/EH' on the other side.Nexium Control is indicated for the short-term treatment of reflux symptoms (e.g.
Symptoms associated with acid reflux (such as heartburn and acid regurgitation) were evaluated retrospectively over a 24 hour period. It is a specific inhibitor of the acid pump in the parietal cell. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. The apparent volume of distribution at steady state in healthy subjects is approximately 0.22 l/kg body weight. If you have been told by your doctor that you have an intolerance to some sugars, talk to your doctor before taking this medicine.Always take this medicine exactly as your doctor or pharmacist has told you. When using the eye drops or ointment take care to not touch the dropper or tube tip to any surface, or to your eye, to avoid contaminating the medicine with germs. As a precaution, concomitant use of esomeprazole and clopidogrel should be discouraged.Concomitant administration of 40 mg esomeprazole resulted in a 13% increase in trough plasma levels of phenytoin in epileptic patients. The investigators' assessments of heartburn resolution were consistent with the subjects' assessments, showing statistically significant differences between esomeprazole (34.7% - 41.8%) compared to placebo (8.0% - 11.4%). May sometimes cause unusual results with medical tests. Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). About 80% of nights were heartburn free during all time periods and 90% of nights were heartburn free by week 2 of each clinical study, compared to 72.4 – 78.3% for placebo. Single doses of 80 mg esomeprazole were uneventful.

In two multicenter, randomized, double-blind, placebo-controlled pivotal studies 234 subjects with a recent history of frequent heartburn were treated with 20 mg esomeprazole for 4 weeks. If lesions occur, especially in sun-exposed areas of the skin, and if accompanied by arthralgia, the patient should seek medical help promptly and the health care professional should consider stopping Nexium Control. The clinical relevance of this interaction is uncertain. Response and Effectiveness. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.These medications may cause some risk when taken together.

Therefore, you should not take Nexium if you are breastfeeding.Nexium is not likely to affect you being able to drive or use any tools or machines.