Maximum dose of Geodon or ziprasidone: Take 100 milligrams twice daily. The risk is believed to increase with dose and duration of therapy. When deciding among the alternative treatments available for the condition needing treatment, the prescriber should consider the finding of ziprasidone’s greater capacity to prolong the QT/QTc interval compared to several other antipsychotic drugs Dose Selection-Oral ziprasidone should be administered at an initial daily dose of 40 mg twice daily with food. hypertension, hyperlipidaemia, diabetes mellitus, smoking) should only be treated with diclofenac after careful consideration. These patients include: (1) 4331 patients who participated in multiple-dose trials, predominantly in schizophrenia, representing approximately 1698 patient-years of exposure as of February 5, 2000; and (2) 472 patients who participated in bipolar mania trials representing approximately 133 patient-years of exposure. (25mg and 50mg suppositories only).100mg suppositories may also be given as a once daily treatment, usually at night. 75-150mg daily, in divided doses (25mg, 50mg and 100mg suppositories only). Hypersensitivity reactions can also progress to Kounis syndrome, a serious allergic reaction that can result in myocardial infarction. As with other NSAIDs, including diclofenac, values of one or more liver enzymes may increase. Inhibition of prostaglandin synthesis may adversely affect the pregnancy and/or the embryo/foetal development. 2014 Feb;34(1):129-33. doi: 10.1097/JCP.0000000000000042.Miceli JJ, Tensfeldt TG, Shiovitz T, Anziano R, O'Gorman C, Harrigan RH.Pharmacotherapy. It works by changing the effects of chemicals in the brain. In particular, it is recommended that the lowest effective dose be used in frail elderly patients or those with a low body weight (see section 4.2 Posology and Method of administration).As with other nonsteroidal anti-inflammatory drugs including diclofenac, allergic reactions, including anaphylactic/anaphylactoid reactions, can also occur without earlier exposure to the drug (see section 4.8 Undesirable effects). In the flexible-dose clinical trials, the mean daily dose administered was approximately 120 mg Continue treatment at the same dose on which the patient was initially stabilized, within the range of 40 mg–80 mg twice daily with food. WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYHOSISSee full prescribing information for complete boxed warning Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death (Ziprasidone hydrochloride is not approved for the treatment of patients with dementia-related psychosis Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-Related Psychosis:Manic and Mixed Episodes Associated with Bipolar Disorder:To report SUSPECTED ADVERSE REACTIONS, contact Aurobindo Pharma USA, Inc. at 1-866-850-2876 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. 75-150mg daily, in divided doses (25mg, 50mg and 100mg suppositories only). Ziprasidone capsules can be used to treat symptoms of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. It is essential to periodically monitor serum electrolytes in patients for whom diuretic therapy is introduced during ziprasidone treatment. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. Dosage adjustments, if indicated, should generally occur at intervals of not less than 2 days, as steady-state is achieved within 1 to 3 days.
Ziprasidone was administered for 24 months in the diet at doses of 2, 6, or 12 mg/kg/day to rats, and 50, 100, or 200 mg/kg/day to mice (0.1 to 0.6 and 1 to 5 times the maximum recommended human dose (MRHD) of 200 mg/day based on mg/m 2 body surface area, respectively). There have been few reports of hyperglycemia or diabetes in patients treated with ziprasidone hydrochloride. Patients who are started on diuretics during ziprasidone therapy need periodic monitoring of serum potassium and magnesium. Since ziprasidone has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about performing activities requiring mental alertness, such as operating a motor vehicle (including automobiles) or operating hazardous machinery until they are reasonably certain that ziprasidone therapy does not affect them adversely.One case of priapism was reported in the premarketing database.
Ziprasidone was administered for 24 months in the diet at doses of 2, 6, or 12 mg/kg/day to rats, and 50, 100, or 200 mg/kg/day to mice (0.1 to 0.6 and 1 to 5 times the maximum recommended human dose (MRHD) of 200 mg/day based on mg/m 2 body surface area, respectively). There have been few reports of hyperglycemia or diabetes in patients treated with ziprasidone hydrochloride. Patients who are started on diuretics during ziprasidone therapy need periodic monitoring of serum potassium and magnesium. Since ziprasidone has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about performing activities requiring mental alertness, such as operating a motor vehicle (including automobiles) or operating hazardous machinery until they are reasonably certain that ziprasidone therapy does not affect them adversely.One case of priapism was reported in the premarketing database.