Thiazide diuretic therapy increases serum urate concentrations by as much as 35%; an effect related to decreased renal clearance of urate, and one that is most prominent in those with the highest pretherapy urate clearance values.First, diuretic-related hyperuricemia does not typically precipitate a gouty attack unless the patient has an underlying gouty tendency or serum urate concentrations routinely exceed 12 mg/dL.Allopurinol should not be routinely started (as often is the case) for asymptomatic diuretic-related hyperuricemia. Although AHS is rare, the number of patients with gout requiring allopurinol is high, and there are sufficient overall cases of AHS to warrant consideration of preventive measures. The study is created by eHealthMe based on reports of 19,431 people who take Allopurinol and Furosemide from the FDA, and is updated regularly. Abstract. 1994 Dec;72(12):1076-81. doi: 10.1007/BF00577759.Löffler W, Landthaler R, de Vries JX, Walter-Sack I, Ittensohn A, Voss A, Zöllner N.Clin Investig. Evidence for interaction: Study. Diuretics may increase the risk of toxic effects of allopurinol. This site does not dispense medical advice or advice of any kind. In the present study, the effect of hydrochlorothiazide administration on the renal clearance and serum half-life of oxipurinol has been studied in eight normal volunteers to determine if thiazides delay the clearance of oxipurinol. In the present study, the effect of hydrochlorothiazide administration on the renal clearance and serum half-life of oxipurinol has been studied in eight normal volunteers to determine if thiazides delay the clearance of oxipurinol. Zyloprim [package insert]. No change in renal oxipurinol clearance (21.1 +/- 5.9 vs. 20.4 +/- 8.7 ml/min) or serum oxipurinol half-life (23.7 +/- 4.2 vs. 23.4 +/- 4.4 hours) was noted with the addition of thiazides. Oftentimes, a diuretic can be restarted at a lower and sometimes still effective dose. You should consult your doctor and take appropriate prescription. 2012 Oct;64(10):1431-46. doi: 10.1002/acr.21772.Eur J Clin Pharmacol. If you take allopurinol with a diuretic, your healthcare provider should periodically test your kidney function (using a simple blood test). If you log out, you will be required to enter your username and password the next time you visit. These side effects may go away during treatment as your body adjusts to the medicine. Hope I answered your query.If you have any questions, I will clarify further. However, allopurinol (a renally-cleared compound) should be used cautiously (dose-adjusted according to level of renal function) in patients receiving a thiazide-type diuretic, since allopurinol hypersensitivity reactions are more common with this combination.Click the topic below to receive emails when new articles are available. Drug interactions have been described between Allopurinol and Diuretics( like Hydrochlorthiazide). Allopurinol is a medicine used to lower levels of uric acid in your blood. San Diego, CA: Prometheus Laboratories, Inc.;2003 October.Lexi-Interact [computer program]. The association previously noted between the use of thiazide diuretics and the development of allopurinol toxicity cannot be explained by alterations in oxipurinol pharmacokinetics. In order for us to create your customized HealthSavvy programs, we need a little more information about the health topic(s) that you are interested in. Allopurinol is used in the treatment of high uric acid levels associated with gout, kidney … 2018 Mar 22;20(1):53. doi: 10.1186/s13075-018-1559-2.Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R; American College of Rheumatology.Arthritis Care Res (Hoboken).
Hi Clipboard, Search History, and several other advanced features are temporarily unavailable. In the patient with preexisting gout and with a need for diuretic therapy, the xanthine oxidase inhibitor, allopurinol, can be considered. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.