The effect that Bentyl has on an unborn child has not been studied extensively. In recent clinical trials, the incidence of central nervous system (CNS) side effects associated with the 100 mg daily dose was at or near the level of placebo.

It has very little or no activity against influenza B virus isolates. If generic versions of this product have been approved by the FDA, there may be Amantadine is an antiviral medicine that blocks the actions of viruses in your body.Amantadine is used to treat and prevent influenza A (a viral infection). Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Symmetrel.
Hyperthermia has also been observed in cases where a drug overdose has occurred.There is no specific antidote for an overdose of Symmetrel. Symmetrel can exacerbate mental problems in patients with a history of psychiatric disorders or substance abuse. One metabolite, an N-acetylated compound, was quantified in human urine and accounted for 5-15% of the administered dose.

Cardiac dysfunction includes arrhythmia, tachycardia and hypertension. Data from earlier animal studies suggest that Symmetrel may have direct and indirect effects on dopamine neurons. Cardiovascular maldevelopment (single ventricle with pulmonary atresia) was associated with maternal exposure to amantadine (100 mg/d) administered during the first 2 weeks of pregnancy. The lowest reported acute lethal dose was 1 gram. If generic versions of this product have been approved by the FDA, there may be Symmetrel (Amantadine Hydrochloride, USP) is designated generically as amantadine hydrochloride and chemically as 1-adamantanamine hydrochloride.Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.Each tablet intended for oral administration contains 100 mg amantadine hydrochloride and has the following inactive ingredients: hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, FD&C Yellow No. Alternatively, temporary discontinuation of Symmetrel for several weeks, followed by reinitiation of the drug, may result in regaining benefit in some patients.

Bentyl should only be used during pregnancy if clearly needed. Following the administration of amantadine 100 mg as a single dose, the mean ± SD red blood cell to plasma ratio ranged from 2.7 ± 0.5 in 6 healthy subjects to 1.4 ± 0.2 in 8 patients with renal insufficiency.The apparent oral plasma clearance of amantadine is reduced and the plasma half-life and plasma concentrations are increased in healthy elderly individuals age 60 and older. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary.Occasionally, patients whose responses are not optimal with Symmetrel at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses.

In a three litter, non-GLP, reproduction study in rats, Symmetrel at a dose of 32 mg/kg/day (equal to the maximum recommended human dose on a mg/m2 basis) administered to both males and females slightly impaired fertility. Pulmonary edema and respiratory distress (including adult respiratory distress syndrome - ARDS) have been reported; renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur.
Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. If there is no record of recent voiding, catheterization should be done.The dose of Symmetrel (Amantadine Hydrochloride, USP) may need reduction in patients with congestive heart failure, peripheral edema, orthostatic hypotension, or impaired renal function (see The adult daily dosage of Symmetrel is 200 mg; two 100 mg tablets (or four teaspoonfuls of syrup) as a single daily dose. Drug overdose has resulted in cardiac, respiratory, renal or central nervous system toxicity. Symmetrel does not completely prevent all cases of the flu, however. for 7 days during the 6th and 7th week of gestation).

However, in two non-GLP studies in rats in which females were dosed from 5 days prior to mating to Day 6 of gestation or on Days 7-14 of gestation, Symmetrel produced increases in embryonic death at an oral dose of 100 mg/kg (or 3 times the maximum recommended human dose on a mg/m2 basis). Follow all directions on your prescription label. The incidence of suicide attempts is not known and the pathophysiologic mechanism is not understood.

Amantadine is approximately 67% bound to plasma proteins over a concentration range of 0.1 to 2.0 μg/mL. Symmetrel should be used during pregnancy only if the potential benefit justifies the potential risk to the embryo or fetus.Symmetrel is excreted in human milk.