However, as has been shown for all beta-blocking agents, the antihypertensive effect does not appear to be related to plasma level.Consistent with its negative chronotropic effect due to beta blockade of the SA node, atenolol tablets increase sinus cycle length and sinus node recovery time. Atenolol excretion would be expected to decrease with advancing age.No significant accumulation of atenolol tablets occur until creatinine clearance falls below 35 mL/min/1.73 m The dose range of atenolol tablets is narrow and increasing the dose beyond 100 mg once daily is not associated with increased antihypertensive effect. Atenolol: Belongs to the class of selective beta-blocking agents.
The reported frequency of these and other events occurring during these investigations is given in the following table.In a study of 477 patients, the following adverse events were reported during either intravenous and/or oral atenolol administration:Development of Ventricular What is this medicine? The 95% confidence limits are 1%-27%. Alternatively, repeat IV dose of 5 mg 10 minutes after the initial dose followed by an oral dose of 50 mg 10 minutes after the last dose. Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.Atenolol tablets should be used with caution in diabetic patients if a beta-blocking agent is required. Atenolol tablets also differ from propranolol in that only a small amount (6%-16%) is bound to proteins in the plasma.

The absolute difference translates into a proportional reduction of 15% (3.89-4.57/4.57 = -0.15).

When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart .This medicine is available only with your doctor's prescription .Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. (See Patients in the atenolol group were to receive atenolol I.V.

Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Inotropic agents were infrequently used. Atenolol belongs to a group of medicines called beta blockers. If an optimal response is not achieved within one week, the dosage should be increased to atenolol 100 mg given as one tablet a day. dose) followed by either atenolol tablets 100 mg once daily or atenolol tablets 50 mg twice daily on days 2-7. Additionally, common effects associated with overdosage of any beta-adrenergic blocking agent and which might also be expected in atenolol tablets overdose are congestive heart failure, hypotension, bronchospasm and/or hypoglycemia.Treatment of overdose should be directed to the removal of any unabsorbed drug by induced emesis, gastric lavage, or administration of activated charcoal. injection 5-10 mg given over 5 minutes plus atenolol tablets 50 mg every 12 hours orally on the first study day (the first oral dose administered about 15 minutes after the I.V. injection 5-10 mg given over 5 minutes plus atenolol tablets 50 mg every 12 hours orally on the first study day (the first oral dose administered about 15 minutes after the I.V.

It contains not less than 90.0 percent and not more than 110.0 percent of the labeled amount of atenolol (C 14 H 22 N 2 O 3). On the other hand, atenolol can increase oxygen requirements by increasing left ventricular fiber length and end diastolic pressure, particularly in patients with heart failure.In a multicenter clinical trial (ISIS-1) conducted in 16,027 patients with suspected myocardial infarction, patients presenting within 12 hours (mean = 5 hours) after the onset of pain were randomized to either conventional therapy plus atenolol tablets (n = 8,037), or conventional therapy alone (n = 7,990).
In the subsequent International Study of Infarct Survival (ISIS-1) including over 16,000 patients of whom 8,037 were randomized to receive atenolol treatment, the dosage of intravenous and subsequent oral atenolol was either discontinued or reduced for the following reasons:During postmarketing experience with atenolol tablets, the following have been reported in temporal relationship to the use of the drug: elevated liver enzymes and/or bilirubin, hallucinations, headache, impotence, Peyronie’s disease, postural hypotension which may be associated with syncope, psoriasiform rash or exacerbation of psoriasis, psychoses, purpura, reversible alopecia, thrombocytopenia, visual disturbance, sick sinus syndrome, and dry mouth.

*Based on the maximum dose of 100 mg/day in a 50 kg patient.Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).Atenolol tablets are available as 25, 50 and 100 mg tablets for oral administration.Inactive Ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate and sodium starch glycolate (potato).In man, absorption of an oral dose is rapid and consistent but incomplete. Atenolol tablets have been studied in combination with thiazide type diuretics, and the blood pressure effects of the combination are approximately additive. Atenolol has been shown to produce a dose-related increase in embryo/fetal resorptions in rats at doses equal to or greater than 50 mg/kg/day or 25 or more times the maximum recommended human antihypertensive dose.