Implementation of intravenous to oral antibiotic switch therapy guidelines in the general medical wards of a tertiary-level hospital in South Africa. <> Undefined. Transitional antibiotic therapy. Delafloxacin is excreted renally and unaffected by cytochrome P450. Kasper S, Muller-Spahn F. Intravenous antidepressant treatment: focus on citalopram. Carcao et al undertook a pilot study to assess the safety and efficacy of an alternative approach that involved a combination of intravenous followed by oral acyclovir in a cohort of immunocompromised children. Early transition to oral antibiotic therapy for community-acquired pneumonia: duration of therapy, clinical outcomes, and cost analysis. Results of a prospective, randomized, double blind comparison of the efficacy and the safety of sequential ciprofloxacin (intravenous/oral)+metronidazole (intravenous/oral) with ceftriaxone (intravenous)+metronidazole (intravenous/oral) for the treatment of intra-abdominal infections. Conversion to oral therapy with ciprofloxacin/metronidazole was as effective as continued intravenous therapy with ceftriaxone and oral metronidazole in patients who were able to tolerate oral feeding.Similarly, in 1996, Solomkin et al reported a study in which patients were randomized to either (1) ciprofloxacin plus metronidazole intravenously or imipenem intravenously throughout their treatment course or (2) ciprofloxacin plus metronidazole intravenously and treatment with oral ciprofloxacin plus metronidazole when oral feeding was resumed, with equal outcomes.Antifungals that can be used for switch therapy include itraconazole and fluconazole.The efficacy and safety of intravenous and oral itraconazole and intravenous and oral fluconazole for long-term prophylaxis of fungal infections in transplantation patients have been established; itraconazole is better tolerated. Conversion to oral therapy with intravenous ciprofloxacin plus metronidazole appeared as effective as continued intravenous therapy in patients able to tolerate oral feedings.In 2003, a trial reported by Drummond et al compared sequential intravenous/oral monotherapy with Similarly, in 2002, Finch et al noted that monotherapy with moxifloxacin is superior to a standard combination regimen of a beta-lactam and a beta-lactamase inhibitor (co-amoxiclav) with or without a macrolide (clarithromycin) in the treatment of patients with CAP admitted to a hospital.Specifically, Finch et al noted the superiority of moxifloxacin irrespective of the pneumonia severity and regardless of whether the combination therapy included a macrolide. Intravenous to oral antibiotic switch therapy. Rhew DC, Tu GS, Ofman J, et al. Fewer deaths (9 [3%] vs 17 [5.3%]) and fewer serious adverse events (38 [12.6%] vs 53 [16.5%]) were reported in the moxifloxacin group than in the comparator group.In June 2017, FDA approved Baxdela (delafloxacin) for the treatment of acute bacterial skin and skin structure infections (ABSSSI).
A program was calculated for each antibiotic, in its oral and intravenous forms, in "defined daily dose/100 stays per day" and in economic terms (drug acquisition cost). Antibiotics ideal for intravenous-to-oral (IV-to-PO) switch programs include chloramphenicol, clindamycin, metronidazole, trimethoprim-sulfamethoxazole, fluconazole, itraconazole, voriconazole, doxycycline, minocycline, levofloxacin, moxifloxacin, and linezolid.Sequential antibiotic therapy ensures an early switch to the oral route when a patient is clinically stable. Parenteral-oral switch in the management of paediatric pneumonia. Handoko KB, van Asselt GJ, Overdiek JW. Available at Adler L, Hajak G, Lehmann K, et al. Oral acyclovir was continued for a total of 7-10 days (intravenous plus oral). endobj Parola D, Dell'Orso D, Terzano C. [Efficacy and safety of clarithromycin in the treatment of community-acquired pneumonia].

Available at Baxdela (delafloxacin) [package insert].


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Sensakovic JW, Smith LG.

The optimal duration of therapy. Pharmacokinetics and safety of voriconazole following intravenous- to oral-dose escalation regimens. The study demonstrated statistical equivalence between intravenous ciprofloxacin plus metronidazole and intravenous imipenem in both the intent-to-treat and valid populations. Carcao et al found that 25 of the 26 patients were successfully switched from intravenous to oral administration after 4.1 (mean) ± 1.2 days (standard deviation) (range, 2.3-6 d).