If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary.Clobetasol Propionate Ointment USP should not be used with occlusive dressings.In studies where geriatric patients (65 years of age or older, see Clobetasol Propionate Ointment USP, 0.05% is supplied in 15-g (NDC 42291-077-15), 30-g (NDC 42291-077-30), 45-g (NDC 42291-077-45), and 60-g (NDC 42291-077-60) tubes.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
These doses are approximately 1.4 and 0.04 times, respectively, the human topical dose of clobetasol propionate cream and ointment. If no improvement is seen within 2 weeks, reassessment of the diagnosis may be necessary.Clobetasol Propionate Ointment USP is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.Clobetasol Propionate Ointment USP should not be used in the treatment of rosacea or perioral dermatitis, and should not be used on the face, groin, or axillae.Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal from treatment.
treatment should be limited to 2 consecutive weeks, and amounts greater than 50 g/week should not be used.Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [See USP Controlled Room Temperature]. Clobetasol Propionate Cream, USP, 0.05% is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.
It also comes as a shampoo.
Because many drugs are excreted in human milk, caution should be exercised when Clobetasol Propionate Ointment USP is administered to a nursing woman.Safety and effectiveness of Clobetasol Propionate Ointment USP in pediatric patients have not been established.
Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Because of a higher ratio of skin surface area to body mass, pediatric patients are at a greater risk than adults of HPA axis suppression and Cushing’s syndrome when they are treated with topical corticosteroids. Do not refrigerate.We comply with the HONcode standard for trustworthy health information -
Clobetasol Propionate Ointment USP should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. Clobetasol is used to treat certain scalp and skin conditions (e.g., psoriasis, dermatitis, rash). It is for external use only. Abnormalities seen included cleft palate and skeletal abnormalities.In rabbits, clobetasol propionate was teratogenic at doses of 3 and 10 mcg/kg. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.Chemically, clobetasol propionate is (11ß,16ß)-21-chloro-9- fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4- diene-3,20-dione, and it has the following structural formula:Clobetasol propionate has the molecular formula C25H32CIFO5 and a molecular weight of 467. (See Clobetasol Propionate Ointment USP is a super-high potency topical corticosteroid; therefore, As with other highly active corticosteroids, therapy should be discontinued when control has been achieved.
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. Adverse effects including striae have been reported with inappropriate use of topical corticosteroids in infants and children.HPA axis suppression, Cushing syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids.A limited number of patients at or above 65 years of age have been treated with clobetasol propionate cream (n = 231) in US and non-US clinical trials. Apply or spray a …
Only externally: Clobetasol is a high-potency steroid which is usually meant for external use only.
As most of the nerve endings are just outside the vaginal opening it would not be of much use internally in any case! Temovate (clobetasol propionate) is a topical medication used to treat a variety of skin conditions that cause an itchy, red, inflamed rash. These doses are approximately 0.02 and 0.05 times, respectively, the human topical dose of clobetasol propionate cream and ointment. Select one or more newsletters to continue. It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk.
It is a potent topical corticosteroid that is anti-inflammatory and anti-itch.
While the number of patients is too small to permit separate analysis of efficacy and safety, the adverse reactions reported in this population were similar to those reported by younger patients.