Nevertheless, since the neutrophils no longer react to the uric acid crystals, arachidonic acids will not be able to get released. A list of drugs that interact with Colchicine. 202 0 obj <>/Filter/FlateDecode/ID[<9A0FAF1FC42DF0459FDAA633AB4EE0D5><9CD57AD2DCBFB04FBC01D36BC4BD449C>]/Index[180 45]/Info 179 0 R/Length 108/Prev 113963/Root 181 0 R/Size 225/Type/XRef/W[1 3 1]>>stream %PDF-1.5 %���� 1 to 2 standard drinks, once or twice a week. h�b```f``��������A�X��,��1~k�ql5``(�( I3 If you plan to have children, talk with your doctor before using this medicine. When taking colchicine keep your alcohol intake to a minimum i.e. 7���� �\�V`�I�v��-f�ሰ�޽�-�ޟ�MF�^~-��I�������դ.�2�*\��]�o8D���r^�\�참{]V�75тg��Mˁ�&;��+ܣż��.�A$H��/]�Qq[;? Do not take more than 12 tablets during any one attack.

Colchicine is taken to ease the pain of a gout attack. ܸ��#��S#�۟� T�� A`V�& ``\��E�Xl�2?��h�����Ԇy�EL]� ;,fէe���U��-n���G����ER/���&LY�I���ѫ��zV�M���#���%�����^,���L�6n���(����j1����y5�WU�U�U}xS,ì��]|�L�^�1�|�,:[|�W��$�:�� �Ѧ���s����S�앑&_w�������V��=^��x���6/��ݎ��g�N��;/f�=Ac� ��;joGͦ���c��Qbw���� 9;��!�ੵ Ӊ���D��k���)hyq������\��oj۝N��j;)���Ї~m� opL� FQ�o7֑�MC)��ڜh؍YΈ����n�(��/��GQtD>��o�`H6a$W�87��#��B4��w��\��s)�n�#��Ν.�L4�H ��h�ci�>��J�����>����M� T3�N���hbHd�,b����ݑ����F8��\'���>��#`x��B�=O)� �|=:�2 'L�'����p�IrFG�&�z�{�kR�4�|dl[L�4*����4���8F�KiU�݊�f�֨�umU�ݏ�n��[7@�{`k����+�b�K#[Q�pMؿ`c�% �Q��9�� Colchicine is an extract of the plant Colchicum autumnale (autumn crocus).
It has been used as a medicine since ancient times. H�\�Kk� ��~�9����IeK!�>h�`t� X�2���"ݞ�H�(� ��6 �FH�����t�3� �@�g`�` 4d Statistically, the colchicine and ibuprofen have zero proven interaction. r�2{�g��U}��X��4-������T�2�|�T��7��K�u4�/���";>�r Colchicine changes the response of the immune system. Do not take other medicines unless they have been discussed with your doctor. Alcohol can trigger an attack of gout. Stomach problems may be more likely to occur if you drink large amounts of alcoholic beverages while using colchicine. Ceritinib is predicted to increase the exposure to colchicine. Manufacturer advises caution and monitor side effects. %%EOF endstream endobj 184 0 obj <>stream If this happens, stop taking colchicine and let your symptoms settle. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. What is colchicine and how does it work? Blood tests may be needed to check for unwanted effects. Take one tablet 2-4 times a day until the pain eases, unless your doctor tells you otherwise.
�CqHr1��Q�a,�$���8�!o?�.�`�'��d�_���� ��[9`�Y�q���.ڰ��e�{���'�pl��̖ ���[���������W�Y��u���ݹ\�(��@�L�^F�:�Dž4��C��_��H�ps�D?��(�t nt:�F���Y5��{�LT1�(�0Qg�#7eb2�u�:r����fn#�2���;- ���{�*m2���v���e� �f}B h�bbd```b``��SA$�j�Vf{�HF��E`��`v� VϜfg��=`� 0 Therefore, people who use colchicine should be careful to limit the amount of alcohol they drink.For patients taking small amounts of colchicine regularly (preventive treatment):Colchicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. How to take Colchicine for a gout attack – for gout attacks, you’d normally take one tablet 2 to 4 times a day until your symptoms are all gone. Also, drinking too much alcohol may increase the amount of uric acid in your blood. h��X�o�8�W�qá�ޒC���n�mh��pE?x��K�"����)K������@0�(��D���P©$9�+�8��0i�4�i�%,��rA8�Dq %#Va�FsP�a�p& S��T��M��(l���1K$7�ɉ�tsЫ-(�(��s����\Å h*%��/^d#džJ6�@u���we6^,��2;'t8�� For patients taking small amounts of colchicine regularly (preventive treatment): endstream endobj 181 0 obj <>/Metadata 20 0 R/Outlines 47 0 R/PageLayout/OneColumn/Pages 178 0 R/StructTreeRoot 50 0 R/Type/Catalog>> endobj 182 0 obj <>/ExtGState<>/Font<>/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 183 0 obj <>stream Colchicine with uric acid-lowering therapy is continued until uric acid is below 6.0. Some men using this medicine have become temporarily infertile (unable to have children). kҘ�b���O�o���� ��1�|���l���Of�������&N a2V\�ˆ���n@o���Ez�I 180 0 obj <> endobj endstream endobj 185 0 obj <>stream H�\��j�0��~

endstream endobj startxref It can also lower the number of platelets, which are necessary for proper blood clotting. It has been found to be helpful in conditions where a person has too many neutrophils (a type of white blood cell) in the skin.

For acute flares coclchine may be increased to three tablets a day for a few days; if there is GI discomfort, the daily dose may be decreased to one tab daily.

All rights reserved. 224 0 obj <>stream You shouldn’t take more than 12 tablets for 1 gout attack.