Dosage and duration of tamoxifen treatment for mastalgia: a controlled trial. You might consider lowering the dose of menopausal hormone therapy or stopping it entirely. Monitor closely for signs of lovastatin toxicity (eg, myositis, rhabdomyolysis).NiMODipine: CYP3A4 Inhibitors (Weak) may increase the serum concentration of NiMODipine. A group of 126 patients with mastalgia who failed to respond to first line therapy and completed further treatment options wa … Guideline recommendations:Danazol may be considered for short-term pre-procedural and long-term HAE prophylaxis as an alternative to CI inhibitor (human). Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. It needs to be taken regularly for 2–3 months for best results. Off Label Uses Cyclic breast pain (mastalgia) associated with benign breast disorders A sensitive test (eg, beta subunit test if available) capable of determining early pregnancy is recommended immediately prior to start of therapy. It should be taken with food to avoid nausea . However, danazol is contraindicated during pregnancy; current guidelines recommend use of other agents in pregnant females (WAO/EAACI [Maurer 2018]).• It is used to treat swelling attacks in people with hereditary angioedema (HAE).• It may be given to you for other reasons. In some cases, when you call to set up an appointment, you may be referred immediately to a breast health specialist.The initial evaluation of your breast pain focuses on your medical history.
Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Danazol is probably the most effective drug for mastalgia, and studies suggest that it is of benefit in about 70% or more of patients with cyclical mastalgia, and somewhat fewer with the non-cyclical form.


Evening primrose oil is helpful for many women. However, adverse effects may force the dose to … Talk with the doctor.• Virilization like in females a deep voice, facial hair, acne, or menstrual changes• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin.• Severe cerebrovascular disease like change in strength on one side is greater than the other, trouble speaking or thinking, change in balance, or vision changes• Blood clots like numbness or weakness on one side of the body; pain, redness, tenderness, warmth, or swelling in the arms or legs; change in color of an arm or leg; chest pain; shortness of breath; fast heartbeat; or coughing up blood• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. To prepare for this discussion:For breast pain, basic questions to ask your doctor include:Your doctor may also assess your personal risk of breast cancer, based on factors such as your age, family medical history and prior history of precancerous breast lesions.Mayo Clinic does not endorse companies or products. Pimozide: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Pimozide.

If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received.The use of danazol for the management of hereditary angioedema (HAE) in pregnancy that is not responsive to preferred therapy has been described in case reports (Altman 2006; Boulos 1994; González-Quevedo 2016; Milingos 2009). Ninety-three patients with severe cyclical mastalgia of more than 6 months duration were randomly selected for treatment with tamoxifen (32 women), danazol (32 women) or placebo (29 women) for six consecutive … Fentiman IS, Caleffi M, Hamed H, Chaudary MA. The vast majority of cases have a benign etiology and reassurance is an important aspect