It gets converted into an active metabolite (T3) in the kidney and liver.

Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. (1994): The influence of desipramine on thyroid hormone metabolism in rat brain. Thase ME, Rush AJ . Levothyroxine, Prescribing information, Hypothyroidism, CKS. Amiodarone has a long half-life and drug interactions may occur several weeks (or even months) after it is stopped. The patient was clinically and biochemically euthyroid for the next 4 years. Thus, the dose of Levothyroxine that results in normal blood levels of TThe authors concluded that body weight should be considered when prescribing Levothyroxine and that the prescribed initial dose should be higher for patients with a heavier weight. (1990): Treatment-resistant depression: Definition and treatment approaches.

Levothyroxine structure is identical to TThe dose of the Levothyroxine for any individual patient is different; the best dose should be able to keep the level of thyroid hormone tests (TIn this study, the authors evaluated the effect of sex, age and body weight on the blood level of thyroid hormone in patients taking Levothyroxine.Younis IR et al 2018 Stable isotope pharmacokinetic studies provide insight into effects of age, sex, and weight on levothyroxine metabolism. (1996): Change in thyroid hormone levels following response to cognitive therapy for major depression. (1990): The impact of medication resistance and continuation pharmacotherapy on relapse following response to electroconvulsive therapy in major depression. In this condition, you have normal blood levels of triiodothyronine and thyroxine, but higher than normal levels of TSH.There are certain factors that can affect blood tests for thyroid problems. (1990): A comparison of triiodothyronine and thyroxine in the potentiation of tricyclic antidepressants. Kirkegaard C, Faber J . Bottom Line. (1981): Altered serum levels of thyroxine, triiodthyronines and diiodothyronines in endogenous depression. (1989a): Treatment of imipramine-resistant recurrent depression. (1969): Enhancement of imipramine antidepressant activity by thyroid hormone. Hamilton M . Nonetheless, in recent years several epidemiologic studies have unanimously reported that between about 5 and 15% of depressed patients become chronically ill, i.e., they fail to recover over a period of several years (Formally, all patients were required to meet the DSM-III-R (Nonremission after administration of at least two chemically different antidepressant medications, each administered in standardized doses for a period of at least 6 weeks: tricyclics and tetracyclics >150 mg/day, selective serotonin reuptake inhibitors (SSRI) >20 mg/day; MAO-inhibitor tranylcypromine >30 mg/day). After that, blood levels are generally checked six months later. 3 In addition, the clearance of some drugs can be increased by the metabolic effects of thyroxine. Applies to the following strengths: 25 mcg (0.025 mg); 50 mcg (0.05 mg); 75 mcg (0.075 mg); 100 mcg (0.1 mg); 125 mcg (0.125 mg); 150 mcg (0.15 mg); 200 mcg (0.2 mg); 300 mcg (0.3 mg); 500 mcg (0.5 mg); 88 mcg (0.088 mg); 112 mcg (0.112 mg); 175 mcg (0.175 mg); 137 mcg (0.137 mg); 13 mcg (0.013 mg); 20 mcg (0.02 mg)/mL; 40 mcg (0.04 mg)/mL; 100 mcg (0.1 mg)/mL; 13 mcg (0.013 mg)/mL; 25 mcg (0.025 mg)/mL; 50 mcg (0.05 mg)/mL; 75 mcg (0.075 mg)/mL; 88 mcg (0.088 mg)/mL; 112 mcg (0.112 mg)/mL; 125 mcg (0.125 mg)/mL; 137 mcg (0.137 mg)/mL; 150 mcg (0.15 mg)/mL; 175 mcg (0.175 mg)/mL; 200 mcg (0.2 mg)/mLTSH levels should generally be suppressed to below 0.1 IU/LMyxedema Coma: Elderly and Patients with Cardiovascular Disease: IV use is associated with cardiac toxicity, therefore, doses at the lower end of the dose range should be used in these populations.US BOXED WARNING: NOT FOR TREATMENT OF OBESITY OR FOR WEIGHT LOSSVery little drug is removed by dialysis because T4 is highly protein bound.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

Frank E, Prien RF, Jarrett RB, Keller MB, Kupfer DJ, Lavori PW, Rush AJ, Weissmann MM . -Adjust dose at 6 to 8-weeks intervals until clinically euthyroid and TSH returns to normal. Campos-Barros A, Meinhold H, Stula M, Müller F, Köhler R, Eravci M, Putzien O, Baumgartner A .