Doxycycline systemic 100 mg (West-ward 3142) Subsequent daily dosage is 1 to 2 mg/lb of body weight given as one or two infusions, depending on the severity of the infection. Doxycycline for Injection, USP FOR IV INFUSION ONLY To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxycycline for Injection, USP and other antibacterial drugs, Doxycycline for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.Doxycycline for Injection is indicated in infections caused by the following microorganisms:Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended. This reaction was shown to be reversible when the drug was discontinued.Tetracyclines are present in the milk of lactating women who are taking a drug in this class.Prescribing doxycycline in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.As with other antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. Doxycycline has bacteriostatic activity against a broad range of Gram-positive and Gram- negative bacteria. The infusion must be completed within 12 hours. It is used to treat or prevent bacterial infections. Patients apt to be exposed to direct sunlight or ultraviolet light, should be advised that this reaction can occur with tetracycline drugs, and treatment should be discontinued at the first evidence of skin erythema.The anti-anabolic action of the tetracyclines may cause an increase in BUN. Doxycycline injection is used to treat or prevent bacterial infections, including pneumonia and other respiratory tract infections. You may report side effects to the FDA at 1-800-332-1088. A recommended minimum infusion time for 100 mg of a 0.5 mg/mL solution is one hour. Cross resistance with other tetracyclines is common.Doxycycline has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections as described in the *Doxycycline has been found to be active against the asexual erythrocytic forms of Plasmodium falciparum, but not against the gametocytes of P. falciparum. (See above As with other tetracyclines, doxycycline forms a stable calcium complex in any bone-forming tissue. Doxycycline is indicated for treatment of infections caused by the following gram-negative microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:Doxycycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:For upper respiratory infections due to group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever.When penicillin is contraindicated, doxycycline is an alternative drug in the treatment of infections due to:In acute intestinal amebiasis, doxycycline may be a useful adjunct to amebicides.Doxycycline is indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.This drug is contraindicated in persons who have shown hypersensitivity to any of the tetracyclines.THE USE OF DRUGS OF THE TETRACYCLINE CLASS DURING TOOTH DEVELOPMENT (LAST HALF OF PREGNANCY, INFANCY AND CHILDHOOD TO THE AGE OF 8 YEARS) MAY CAUSE PERMANENT DISCOLORATION OF THE TEETH (YELLOW-GRAY-BROWN). Parenteral therapy is only indicated when oral therapy is not indicated and should not be continued over a prolonged period of time.

Oral therapy should be instituted as soon as possible. These conditions disappeared rapidly when the drug was discontinued.Hemolytic anemia, thrombocytopenia, neutropenia and eosinophilia have been reported.When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of thyroid glands. Therapy must continue for a total of 60 days. Evidence of embryotoxicity has also been noted in animals treated early in pregnancy.The use of doxycycline for injection in children under 8 years is not recommended because safe conditions for its use have not been established. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. For children over 100 pounds the usual adult dose should be used (see In the treatment of inhalational anthrax (post-exposure) the recommended dose is 1 mg/lb (2.2 mg/kg) of body weight, twice a day in children weighing less than 100 lb (45 kg).

They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form.Following a single 100 mg dose administered in a concentration of 0.4 mg/mL in a one-hour infusion, normal adult volunteers averaged a peak of 2.5 mcg/mL, while 200 mg of a concentration of 0.4 mg/mL administered over two hours averaged a peak of 3.6 mcg/mL. Parenteral therapy is only indicated when oral therapy is not indicated and should not be continued over a prolonged period of time. THE USUAL DOSAGE AND FREQUENCY OF ADMINISTRATION OF DOXYCYCLINE FOR INJECTION (100 to 200 MG/DAY) DIFFERS FROM THAT OF THE OTHER TETRACYCLINES (1 to 2 G/DAY).

Reconstituted solutions (1 to 0.1 mg/mL) may be stored up to 72 hours prior to start of infusion if refrigerated and protected from sunlight and artificial light. Solutions must be used within these time periods or discarded.Diluted solutions (0.1 to 1 mg/mL) prepared using Normosol-M® in D5-W (Abbott); Normosol-R® in D5-W (Abbott); Plasma-Lyte® 56 in 5% Dextrose (Baxter); or Plasma-Lyte® 148 in 5% Dextrose (Baxter) may also be stored up to 12 hours prior to start of infusion, if refrigerated and protected from sunlight and artificial light.