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0000083599 00000 n 0000019103 00000 n Etoposide, the active moiety of etoposide phosphate is teratogenic in mice and rats see Data). <<4B3E0876D21DB2110A0005F71076D4FF>]/Prev 399524/XRefStm 3502>> 0000014162 00000 n 0000003858 00000 n �N3YYl�'�p�mS`��m``����M�F;������K�4#+�0044� �+10O��30�0 �m7, endstream endobj 36 0 obj <> endobj 37 0 obj <> endobj 38 0 obj <> endobj 39 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/Properties<>>> endobj 40 0 obj <>stream 0000002027 00000 n %PDF-1.4 %���� 0000002737 00000 n 0000010305 00000 n 663 0 obj Advise women of childbearing potential to avoid becoming pregnant. 0000173868 00000 n In the U.S. general population, the estimated background risk of major birth defects and 0000001654 00000 n endobj 0000034825 00000 n 0000011901 00000 n 0000001316 00000 n b}��#���p��c`q�h��U��b�'pı������ <>stream h�b``�e``�a`c`T�� Ȁ �@16���I@~ 걵'����qܑD^�N���"��BV���� f1��������`c����9� �6 b#��*?��� �|�1��,� 0000017091 00000 n 0000017639 00000 n 0000088509 00000 n 0000057853 00000 n 0000085248 00000 n
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0000010936 00000 n 0000173761 00000 n In rats, an intravenous etoposide dose of 0.4 mg/kg/day (about 1/20th of the human dose on a mg/m 2 basis) during organogenesis caused maternal toxicity, embryotoxicity, and teratogenicity
0000091815 00000 n [�L���.�����2�!�")7L,�J�R W��*�l��M�l�J.4��q��>S% ��p�>�b`�`D Click to view Etoposide Pfizer detailed prescribing information Dosage/Direction for Use Adult 50-60 mg/m 2 daily by slow IV infusion over 30-60 min for 5 consecutive days followed by treatment-free interval of 2-3 wk. 0000002776 00000 n 0000007101 00000 n 0000003502 00000 n Etoposide should be administered under the supervision of a qualifi ed physician experienced in the use of cancer chemotherapeutic agents.
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0000023572 00000 n 0000005120 00000 n 0000106200 00000 n trailer 0000008636 00000 n 0000019461 00000 n Etoposide Injection, USP by Hospira: Etoposide belongs to the group of cancer-fighting medications called antineoplastics. startxref
It is very soluble in methanol and chloroform, slightly soluble in ethanol and sparingly soluble in water and ether. 0000007713 00000 n
Severe myelosuppression with resulting infection or bleeding may occur. 0000014725 00000 n 0000009710 00000 n The mean renal clearance of etoposide is 7 mL/min/m 2 to 10 mL/min/m 2 or about 35% of the total body clearance over a dose range of 80 mg/m 2 to 600 mg/m 2. 0000057266 00000 n �R[�����(��)#9�p��څ:�b�l�Y��R����maR����=��|*$�R�Lʗ�
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For recommended dosing adjustments in patients with renal impairment see PACKAGE INSERT … Call your doctor at once if you have: sudden chest pain or discomfort, wheezing, dry cough or hack; 0000086818 00000 n
0000029179 00000 n 0000005424 00000 n �� 0000007866 00000 n 0000029072 00000 n ETOPOPHOS (etoposide phosphate) for Injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in single-dose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32.7 mg sodium citrate USP, and 300 mg dextran 40. trailer <<469CFD9BBEED40BAAFFB2BDE0BE8691B>]/Prev 234541>> startxref 0 %%EOF 85 0 obj <>stream hxyTS������\�Ŗ�ZK���:�j���:+ 0000019912 00000 n
0000081992 00000 n It has a molecular weight of 588.58 and a molecular formula of C29H32O13.Et…
0000226649 00000 n Etoposide (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. 0000007560 00000 n It is made more miscible with water by means of organic solvents. The effect of renal disease on plasma etoposide clearance is not known. 0000013887 00000 n 0000106146 00000 n 0000061414 00000 n In small cell lung cancer, the Etoposide Injection dose in combination with other approved chemotherapeutic drugs ranges from 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days.
Etoposide kills cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction.