This product may be unsafe when used before surgery or other medical procedures. Select one or more newsletters to continue. It is a bitter tasting alkaloid, which is Nature’s way of saying “don’t eat me.” For centuries though, colchicine has been used to treat gout, an acute inflammatory arthritis afflicting (typically) the big toe. Unable to load your collection due to an error Information from this source is evidence-based and objective, and without commercial influence. Keep in mind that natural products are not always necessarily safe and dosages can be important. It appears to decrease inflammation, inhibit collagen synthesis, and increase collagen degradation, thereby slowing disease progression and fibrosis and perhaps extending survival time.A controlled, randomized, prospective trial of 26 patients treated with colchicine or prednisone showed no improvement with either agent.Colchicine 1 to 2 mg is a typical oral dose for gout, corresponding to crocus seed 200 mg or corm 250 mg. Colchicine also has been studied for osteoarthritis of the kneeInformation regarding safety and efficacy in pregnancy and lactation is contradictory.A medical botany text lists autumn crocus as a mutagen and teratogen.Women and their male partners planning pregnancy should avoid use of autumn crocus because of potential complications and limited data available for use in humans.Autumn crocus should be avoided in patients on colchicine because of the potential for additive adverse and therapeutic effects.Colchicine is listed as a substrate of CYP3A4 (cytochrome P450) hepatic metabolism enzyme.The following medications/herbs have demonstrated interactions that warrant close observation or discontinuation of autumn crocus (colchicine).Up to 50% of renal transplant recipients on concurrent cyclosporine and colchicine therapy experience myopathies, rhabdomyolysis, and neuromyopathy.A case of rhabdomyolysis potentially caused by concurrent gemfibrozil and colchicine therapy was reported.Colchicine toxicity was reported with coadministration of erythromycin or clarithromycin.Colchicine is a substrate of CYP3A4, which St. John's wort induces.

Colchicine 1 to 2 mg is a typical oral dose for gout, corresponding to crocus seed 200 mg or corm 250 mg. Colchicine also has been studied for osteoarthritis of the knee, refractory constipation, and postpericardiotomy syndrome at similar doses.

2006 May;118(9-10):294-7. doi: 10.1007/s00508-006-0581-6.

It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). It has been found to be helpful in conditions where a person has too many neutrophils (a type of white blood cell) in the skin. 2006 Mar 23;148(12):45-7. doi: 10.1007/BF03364609.Kicka M, Olszowy Z, Jankowski Z, Celiński R, Kłopotowski T, Bazylewicz A, Miśkiewicz Ł, Picheta S.J Med Case Rep. 2007 Aug 12;1:64. doi: 10.1186/1752-1947-1-64.Wien Klin Wochenschr.

The solution may vary in colchicine concentration since concentrations of colchicine vary from bulb to bulb. Can anyone suggest a how-to description online? Compared to the crocus, they look as if they are on steroids but in fact it is the product of colchicine which is extracted from them. Colchicum, Colchicum autumnale, Colchicum speciosum, Colchicum vernum, Colchique, Colchique d'Automne, Cólquico, Crocus, Dame Sans Chemise, Fall Crocus, Faux-Safran, Gowri Gedde, Meadow Saffran, Meadow Saffron, Mysteria, Naked Ladies, Naked Lady, Safran Bâtard, Safran des Prés, Son-Before-The-Father, Tue-Chien, Tue-Loup, Upstart, Vellorita, Wild Saffron, Wonder Bulb.Autumn crocus contains colchicine. This information should not be used to decide whether or not to take this product. Information from this source is evidence-based and objective, and without commercial influence. Epub 2004 Jan 2.Klintschar M, Beham-Schmidt C, Radner H, Henning G, Roll P.Forensic Sci Int. Brvar M, Ploj T, Kozelj G, Mozina M, Noc M, Bunc M.Crit Care. (check all that apply) It also may interfere with the normal function of cyclic adenosine monophosphate (cAMP) or the cellular membrane.The plant and its extracts are used to treat gout and related inflammatory disorders.Research reveals no animal or clinical data regarding the use of autumn crocus for gout.

Its narrow therapeutic index requires medical supervision. As you know, colchicine is an alkaloid that is used (among other things) to induce polyploidy in plants. The tuber of this plant is rich in terms of colchicine. Avoid use.Avoid use in patients taking colchicine.


(check all that apply)Where did you or where do you plan to purchase this product?What factors are most important to you? This perennial herb grows to approximately 0.3 m in height and has pale purple flowers and a fleshy conical root (corm). At this time there is not enough scientific information to determine an appropriate range of doses for autumn crocus.
The tuber of this plant is rich in terms of colchicine. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. PubMed:Case report: fatal poisoning with Colchicum autumnale. This information is not specific medical advice and does not replace information you receive from your health care provider.