Abstract

Ziegler DK, Hurwitz A, Preskorn S, Hassanein R, Seim J. Propranolol and Amitriptyline in Prophylaxis of MigraineCustomize your JAMA Network experience by selecting one or more topics from the list below.From the Departments of Neurology (Dr Ziegler), Medicine (Dr Hurwitz), and Biometry (Dr Hassanein and Ms Seim), University of Kansas Medical Center, Kansas City; and Department of Psychiatry, University of Kansas Medical Center-Wichita (Dr Preskorn). Please enable it to take advantage of the complete set of features! Headache scores from daily diaries were calculated at monthly intervals, as were simultaneous blood levels of drug, supine and standing blood pressure, pulse rise with exercise, and salivary flow.—Outpatient headache clinic at the University of Kansas Medical Center, Kansas City.—Thirty consecutive patients with a history of frequent migraine.—From headache scores, patients were classified as either propranolol responders, amitriptyline responders, or nonspecific responders. Prescribed for Chronic Myofascial Pain, Anxiety and Stress,... View. As a beta blocker, propranolol is primarily used for cardiac conditions such as high blood pressure and heart rate irregularity. Propranolol response was associated with attacks of greatest duration at baseline and with low pulse rise with exercise at baseline. Tricyclic antidepressants, including amitriptyline, doxepin, nortriptyline (Pamelor), and protriptyline, are used in migraine prevention, but … Epub 2015 Dec 29.Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, Sehgal N, Kuester J.PLoS One. The comparative efficacy of propranolol and amitriptyline in the prophylaxis of migraine headache was studied in 30 patients in a double-blind, placebo-controlled, crossover design. 2015;2015:629382. doi: 10.1155/2015/629382. Silverchair Information Systems eCollection 2015. Propranolol slows down your heart rate and makes it easier for your heart to pump … sign up for alerts, and moreto download free article PDFs, Key facts.

The way the drug helps to prevent migraine headaches is still not well-known. Amitriptyline significantly reduced the severity, frequency, and duration of headache attacks; propranolol reduced the severity of attacks only. Ziegler DK, Hurwitz A, Preskorn S, Hassanein R, Seim J.Arch Neurol.

Amitriptyline response was correlated with female gender and baseline headaches of shortest duration and of … Both drugs were superior to placebo. 2017 Jun;96(22):e6989. Unable to load your delegates due to an error Clinical variables as predictors of response to medications were studied, as were effects on frequency, duration, and/or severity of headache.—No significant correlations were found between changes in headache score and blood level of drug or change in any of the physiologic measurements. Headache response to medication was measured monthly by compilation of headache scores derived from quantitative data First-line therapies for migraine prophylaxis in adults include propranolol (Inderal), timolol (Blocadren), amitriptyline, divalproex (Depakote), sodium valproate, and topiramate (Topamax… It's also prescribed to treat a certain type of adrenal gland tumor (a small gland above the kidneys). 2017 Feb 17;2(2):CD003225. The effectiveness of neither drug correlated with a decrease in anxiety or depression demonstrated by psychological testing.

Headache response to medication was measured monthly by compilation of headache scores derived from quantitative data recorded by patients in a daily diary; at each visit, Zung and Hamilton tests for depression and the Spielberger state test for anxiety were performed. Our website uses cookies to enhance your experience. 1993 Aug;50(8):825-30. doi: 10.1001/archneur.1993.00540080036010.Dodick DW, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg SJ, Hulihan J; CAPSS-277 Investigator Group.Clin Ther. doi: 10.1002/14651858.CD003225.pub3.Pain Res Treat. Silverchair Information Systems Propranolol. As an antidepressant, amitriptyline increases the levels of neurotransmitters in the brain that affect mood and well-being—specifically, serotoninand norepinephrine. doi: 10.1001/archneur.1987.00520170016015. doi: 10.1371/journal.pone.0130733. doi: 10.1097/MD.0000000000006989.Cochrane Database Syst Rev. Unable to load your collection due to an error 2009 Mar;31(3):542-59. doi: 10.1016/j.clinthera.2009.03.020.Cephalalgia. 2011 Jan;51(1):33-51. doi: 10.1111/j.1526-4610.2010.01800.x.

The effects of amitriptyline on these two brain chemicals are thought to help prevent migraine headaches (as well as chronic tension-type headaches and so… All Rights Reserved 1993;50(8):825-830. doi:10.1001/archneur.1993.00540080036010—To determine if the effectiveness of propranolol hydrochloride and amitriptyline hydrochloride are correlated with blood levels and/or with standardized test of pharmacologic effect and to determine which clinical variables are predictors of response to one or the other medication.—Three-month modules of treatment with each drug and placebo in a randomized crossover design.

Neither drug was superior to the other. By continuing to use our site, or clicking "Continue," you are agreeing to our 2020 American Medical Association. Amitriptyline significantly reduced the severity, frequency, and duration of headache attacks; propranolol reduced the severity of attacks only. All Rights Reserved.to download free article PDFs, In the absence of clinical toxicity at monthly visits, the decision to maintain the current dose or raise it was made by a computer, which compared current headache score with that of the previous month. Remove Propranolol from your drug comparison. sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto access your subscriptions, sign up for alerts, and moreto download free article PDFs, sign up for alerts, customize your interests, and moreto make a comment, download free article PDFs, sign up for alerts and more In addition, …