Trough levels should not exceed 2µg/ml administering gentamicin twice daily and 1µg/ml for a once daily dose.Prolonged use should be avoided and whenever possible the treatment should not exceed 7 days.Caution is advised in significant obesity as gentamicin is poorly distributed into fatty tissue. Gentamicin may be removed from the body by haemodialysis or peritoneal dialysis.
Some animal studies have shown a teratogenic effect.Gentamicin is excreted in breast milk, but is unlikely to be a hazard to the infant except in the presence of maternal renal insufficiency when breast-feeding should be avoided, as the levels in breast milk then rise appreciably. It is important to adjust the frequency of dosage according to the degree of renal function.Ototoxicity has been recorded following the use of gentamicin.
By continuing to browse the site you are agreeing to our policy on the use of cookies. Doxycycline (IV/PO) 1-2 mg/kg/dose (Max: 100 mg/dose) Q12 Fluconazole (IV/PO) 6-12 mg/kg/dose day 1, then 3 - 6 mg/kg/dose Q24 Gentamicin >7 days - < 30 days: 4 mg/kg/dose Q24 (Consult: Pharmacy to > 30 days: 2.5 mg/kg/dose Q8 dose) 1st week of life ONLY :Postmenstrual Age < 29 weeks: 5 mg/kg Q48 30 - 34 weeks: 4.5 mg/kg Q36 Select one or more newsletters to continue. However, if penicillins (such as ticarcillin) are used with gentamicin the drugs should not be physically mixed and patients with poor renal function should be monitored for effectiveness of the gentamicin. Target trough level < 1mg/L. The potential nephrotoxicity of other aminoglycosides, vancomycin, ciclosporin, cisplatin, fludarabine and amphotericin may be increased in the presence of gentamicin and monitoring of renal function is therefore recommended.Any potential nephrotoxicity of cephalosporins, and in particular cephaloridine, may also be increased in the presence of gentamicin. Dose or dose per kg used (e.g.
Monitoring: Check level every 24 hours until < 1mg/l. Continue typing to refine. Drugs Normally this will dissolve in the solution, but under some circumstances small bubbles may form.Dilution in the body will obviate the danger of physical and chemical incompatibility and enable this product to be given concurrently with the drugs listed above either as a bolus injection into the drip tubing with adequate flushing, or at separate sites.
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Adjust the dose in 12.5 mcg to 25 mcg increments every 2 to 4 weeks until the patient is clinically euthyroid and the serum TSH level is normalized. and formulary information changes. In particular the following are incompatible in mixed solution: penicillins, cephalosporins, erythromycin, lipiphysan, heparins and sodium bicarbonate. 2010 In patients with severe longstanding hypothyroidism, start with a dose of 12.5 mcg to 25 mcg per day. Repeat 2.5mg/kg stat dose when levels <1mg/L.
Gentamicin should only be used where the seriousness of the mother's condition justifies the risk and use is considered essential by the physician. Due to the longer half-life, newborns are given the required daily dose in one single dose.Gentamicin is normally administered intramuscularly but may be given intravenously as a slow intravenous injection over at least 3 minutes or short infusion if required. daily dosing) Target serum concentration for once-daily gentamicin: 12 hours post dose = <2mg/L 18 hours post dose = <1mg/L *Use ideal body weight (IBW) rather than actual body weight (ABW) because gentamicin distributes poorly in fat.
höher bei kritisch kranken Patienten, z.B.
�1�G�5���^��a��h@�)^���s��-��h���a���Y���L�A��� ��OD�� Cross-sensitivity with aminoglycosides may occur.Safety for use in pregnancy has not been established. 2002
The dose is usually 2 to 3 mcg per kg of body weight per day.