The formulation does not contain a preservative and is for single use only. Clinical particulars. Dietary salt restriction and potassium supplementation may be necessary. The solution of the reconstituted product should be inspected visually for particulate matter and discoloration prior to administration. Adverse effects on fertility in rats with corticosterone were observed in males only and were reversible (see section 5.3). Hydrocortisone 100mg/ml solution for injection . Pharmaceutical form. doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Physicians using the drug should be prepared to deal with such a possibility. Prophylaxis with normal intramuscular immuneglobulin may be needed.Live vaccines should not be given to individuals with impaired immune responsiveness. This is not a list of all drugs or health problems that interact with hydrocortisone injection solution. Use hydrocortisone injection solution as ordered by your doctor. In patients who have received more than physiological doses of systemic corticosteroids (approximately 30 mg hydrocortisone) for greater than 3 weeks, withdrawal should not be abrupt.

Read all information given to you. Hydrocortisone should be reconstituted by adding not more than 2ml of sterile Water for injections to the contents of one vial. If you think there has been an overdose, call your poison control center or get medical care right away. Call your doctor for medical

Continue typing to refine. Corticosteroids should not be stopped and the dose may need to be increased.Exposure to measles should be avoided. Risks may be higher with high doses/systemic exposure (see also section 4.5 Interaction with Other Medicaments and Other Forms of Interaction that can increase the risk of side effects), although dose levels do not allow prediction of the onset, type, severity or duration of reactions. Be ready to tell or show what was During prolonged corticosteroid therapy, these patients should receive chemoprophylaxis.Rarely anaphylactoid reactions have been reported following parenteral Hydrocortisone therapy. When suggestions are available use up and down arrows to review and ENTER to select. You may also report side effects at https://www.fda.gov/medwatch. Hydrocortisone is dialysable.Hydrocortisone sodium succinate has the same metabolic and anti- inflammatory actions as hydrocortisone. Discontinuation of corticosteroids may result in clinical remission.Pheochromocytoma crisis, which can be fatal, has been reported after administration of systemic corticosteroids.

The desired effects of hypoglycaemic agents (including insulin), anti- hypertensives and diuretics are antagonised by corticosteroids, and the hypokalaemic effects of acetazolamide, loop diuretics, thiazide diuretics and carbenoxolone are enhanced.5. Osteoporosis (post-menopausal females are particularly at risk).3. Salicylates and non- steroidal anti-inflammatory agents should be used cautiously in conjunction with corticosteroids in hypothrombinaemia.7. Qualitative and quantitative composition. The clinical relevance of this information is uncertain.The effect of corticosteroids on the ability to drive or use machinery has not been systematically evaluated. These would include depressive or manic-depressive illness and previous steroid psychosis.Systemic corticosteroids are not indicated for, and therefore should not be used to treat traumatic brain injury or stroke because it is unlikely to be of benefit and may even be harmful.

Solution for injection. This dose may be repeated at intervals of 2, 4 or 6 hours as indicated by the patient's response and clinical condition.

Drugs which inhibit the CYP3A4 enzyme, such as cimetidine, erythromycin, ketoconazole, itraconazole, diltiazem and mibefradil, may decrease the rate of metabolism of corticosteroids and hence increase the serum concentration.4. If affected, patients should not drive or operate machinery.Since Hydrocortisone is normally employed on a short-term basis it is unlikely that side-effects will occur; however, the possibility of side-effects attributable to corticosteroid therapy should be recognised (see Section 4.4). • Patients repeatedly taking doses in the evening.Patients should carry 'Steroid Treatment' cards which give clear guidance on the precautions to be taken to minimise risk and which provide details of prescriber, drug, dosage and the duration of treatment.Corticosteroids may mask some signs of infection, and new infections may appear during their use. Prophylactic antacid therapy may be indicated.Patients subjected to severe stress following corticoid therapy should be observed closely for signs and symptoms of adrenocortical insufficiency.Corticosteroid therapy is an adjunct to, and not a replacement for, conventional therapy.In patients with liver disease, there may be an increased effect (see section 4.4) and reduced dosing may be considered.However, treatment of elderly patients should be planned bearing in mind the more serious consequences of the common side-effects of corticosteroids in old age and close clinical supervision is required (See Section 4.4).For intravenous infusion, first prepare the solution by adding not more than 2 ml of sterile water for injections to the vial; this solution may then be added to 100 ml -1000 ml (but not less than 100 ml) of 5% dextrose in water (or isotonic saline solution or 5% dextrose in isotonic saline solution if patient is not on sodium restriction).When reconstituted as directed the pH of the solution will range from 7.0 to 8.0 and the appearance of the solution is clear and colourless to almost colourless.- where there is known hypersensitivity to the active substance or any of the excipients listed in section 6.1- in systemic fungal infection unless specific anti-infective therapy is employed.Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids.A Patient Information Leaflet is provided in the pack by the manufacturer.Undesirable effects may be minimised by using the lowest effective dose for the minimum period. Learn how to administer an emergency injection - practise makes perfect! Solu-Cortef injection contains the active ingredient hydrocortisone sodium succinate, which is a type of medicine known as a corticosteroid.