B. et al. 2020 Jan 10;10:916. doi: 10.3389/fendo.2019.00916. Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis.

Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects.

Free PMC article Please enable it to take advantage of the complete set of features! Ibuprofen increases gonadotropins and decreases AMH in adult men.

Use of non-prescription analgesics and male reproductive function. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Epub 2018 Apr 16.Eur Urol. You can also search for this author in

Epub 2018 Mar 20.Young J, Couzinet B, Chanson P, Brailly S, Loumaye E, Schaison G.J Clin Endocrinol Metab. Ibuprofen increases gonadotropins and decreases AMH in adult men. HighWire 2020 Aug 14:1-12. doi: 10.1007/s10787-020-00745-z. Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (The authors would like to thank Brian Chase, biostatistician in the Department of Urology, University of Kansas Health System, for his comments on the statistics of the paper under discussion.Department of Urology, University of Kansas Health System, Kansas City, KS, USAYou can also search for this author in (The steroid screen identifies ibuprofen as an inhibitor of steroidogenesis in the human NCI-H295R cell line. 2016 Mar;174(3):399-407. doi: 10.1530/EJE-15-0938.

Kristensen, D. M. et al. A.N. Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders.

(Ibuprofen affects Sertoli cell activity in human testicular explants. COVID-19 is an emerging, rapidly evolving situation. Unable to load your delegates due to an error

You are using a browser version with limited support for CSS. Nature Reviews Urology and JavaScript.A recent study suggests modulation of luteinizing hormone signalling within the hypothalamic–pituitary–gonadal axis and downstream transcriptional effects caused by sustained ibuprofen use. Natl Acad. Han, S. et al. 2012 Nov-Dec;33(6):1111-8. doi: 10.2164/jandrol.112.017160. 2000 Sep;85(9):3239-44. doi: 10.1210/jcem.85.9.6811.Munkboel CH, Larsen LW, Weisser JJ, Møbjerg Kristensen D, Styrishave B.Toxicol Sci. Get the most important science stories of the day, free in your inbox. However, this study cannot be used to draw any clinical conclusions regarding effects of ibuprofen on male androgenic or reproductive health. Epub 2019 Nov 12. "Our immediate concern is for the fertility of men who use these drugs for a long time," biomedical researcher David Møbjerg … ( Ibuprofen decreases gene expression in peritubular cells but does not affect germ cells… Ibuprofen decreases PGE2 and PGD2 production and PTGS gene expression in human testicular… Ibuprofen dose-dependently reduces prostaglandin levels… Ibuprofen dose-dependently reduces prostaglandin levels and mRNA expression in human endocrine NCI-H295R cells.… In a new study, scientists show the common painkiller ibuprofen can have a negative impact on testicular health, altering hormone production and inducing a condition called compensated hypogonadism, which affects reproductive health in men. (Ibuprofen decreases gene expression in peritubular cells but does not affect germ cells or morphology in human testicular explants. eCollection 2020 Apr.Smart L, Fawkes N, Goggin P, Pennick G, Rainsford KD, Charlesworth B, Shah N.Inflammopharmacology. ( Ibuprofen inhibits Leydig cell hormone production in human testicular explants. This site needs JavaScript to work properly.