This medicine is available only with your doctor's prescription. CONCLUSION: In this study, a single dose (300/12.5-mg) of the test formulation of irbesartan and hydrochlorothiazide FDC tablet in fasting healthy Chinese male volunteers met WHO's and China's FDA regulatory criteria for assumption of bioequivalence to the reference formulation based on AUC and Cmax.
Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water.Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.7Irbesartan and Hydrochlorothiazide Tablets USP are available for oral administration in tablets containing 150 mg or 300 mg of irbesartan combined with 12.5 mg of hydrochlorothiazide or 300 mg of irbesartan combined with 25 mg hydrochlorothiazide. Monitor serum electrolytes periodically.Hyperuricemia may occur or frank gout may be precipitated in certain patients receiving thiazide therapy.Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.The antihypertensive effects of the drug may be enhanced in the post-sympathectomy patient.Thiazides may decrease urinary calcium excretion. The primary treatment is to discontinue drug intake as rapidly as possible. Store at room temperature away from moisture and heat.Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.

The antihypertensive effect of ARBs may be attenuated by NSAIDs. Learn about reported side effects, related medication class, and daily life interactions. Closely monitor blood pressure, renal function, and electrolytes in patients on Irbesartan and Hydrochlorothiazide Tablets and other agents that affect the RAS.In most patients no benefit has been associated with using two RAS inhibitors concomitantly.

This lowers blood pressure and increases the supply of blood and oxygen to the heart.

All rights reserved. It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. It works by blocking a substance in the body that causes the blood vessels to tighten. Do not take two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Drinking alcohol can further lower your blood pressure and may cause side effects.Do not use potassium supplements or salt substitutes, unless your doctor has told you to.In rare cases, hydrochlorothiazide and irbesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, This is not a complete list of side effects and others may occur.
AVALIDE ® (irbesartan and hydrochlorothiazide) tablets are indicated for the treatment of hypertension.

In patients with renal disease,  thiazides may precipitate azotemia. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.

This lowers blood pressure and increases the supply of blood and oxygen to the heart.

Irbesartan and Hydrochlorothiazide Tablets USP 300 mg/25 mg is Pinkish brown, oval shaped, biconvex, film coated tablets, debossed with “L182” on one side and plain on other side.Thiazides cross the placenta, and use of thiazides during pregnancy is associated with a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. (irbesartan-hydrochlorothiazide) 150/12.5 mg and 300/12.5 mg film-coated tablets are peach, biconvex, and oval with a heart debossed on one side and "2875" or "2876" on the reverse side, respectively. Available for Android and iOS devices. Inactive ingredients include: colloidal silicon dioxide, … It is taken by mouth.