150. Zavorotnyy M, Diemer J, Patzelt J, Behnken A, Zwanzger P.World J Biol Psychiatry. © The Royal Australian and New Zealand College of Psychiatrists 2015. 2012 Mar;5(1):11-7. doi: 10.1016/j.ajp.2011.12.002.

ECT and lithium in old age depression – cause or treatment of rapid cycling?

300–450. Age category (years) Target lithium level a (mmol/L) Approximate lithium daily dose b (mg/day) Starting dose b (mg/day) 45–59. Unable to load your collection due to an error Lithium clearance decreases as the glomerular filtration rate decreases with increasing age.

Ceasing lithium prior to ECT may carry a risk of URC or UURC in BPAD1. There are no placebo-controlled randomised trials of lithium in old age and recommendations for clinical use are based on extrapolations from pharmacokinetic studies, anecdotal reports from mixed age populations and clinical experience in old age psychiatry. Serum concentrations of lithium need to be markedly reduced in the elderly population and particularly so in the very old and frail elderly. The composition of the human body changes with aging producing an increase in body fat, a decrease in fat-free mass and a decrease in total body water.

Reduced lithium clearance is expected in patients with hypertension, congestive heart failure or renal dysfunction. doi: 10.2165/00002512-200016030-00002. 2009;10(4 Pt 3):987-90. doi: 10.1080/15622970802626572.Asian J Psychiatr.

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The authors review the available data concerning the pharmacokinetics and clinical use of lithium carbonate in old age. ScienceDirect ® is a registered trademark of Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V.

Atypon doi: 10.2165/00002512-200016030-00002. ScienceDirect ® is a registered trademark of Elsevier B.V.The clinical use of lithium carbonate in old age: A reviewScienceDirect ® is a registered trademark of Elsevier B.V. July 14, 2020. in Articles, Research Articles, Research Center.

Psychiat. It was first noted several years ago that elderly individuals required lower doses of lithium to achieve serum concentrations similar to those observed in younger adults.
The recommended upper limits of lithium in the serum in this survey were also well below those recommended by others, implying that our experts believe that a lower concentration of lithium may be more effective in later than early life, or that concerns about adverse effects demand greater caution when using lithium in older age. 2017 Oct;43(5):464-470. doi: 10.1016/j.encep.2016.09.005. What is Lithium? 2019 May;189(1):18-27. doi: 10.1007/s12011-018-1455-2.
Lithium dosage was examined in 3 age groups (⩽ 45 years, 46–64 years, ⩾ 65 years) of 78 inpatients, matched on relevant variables. 0.4–0.8. Differences in the response to lithium are explained, in part, by the effect of age-related physiological changes, comorbid conditions, and concurrent medications on the pharmacokinetics of lithium in the elderly. Australasian Psychiatry 2015 23: 5, 500-502 Download Citation. “Elderly” was defined as ≥65 years, as in most of the studies we examined.

Clipboard, Search History, and several other advanced features are temporarily unavailable. The ratio of weight-related lithium dose to plasma level showed a 36% decline with age (0.58, 0.46 and 0.37 1/kg, We use cookies to help provide and enhance our service and tailor content and ads.