QT prolongation can cause irregular heart beats that can be life threatening.General information about the safe and effective use of NizoralWe comply with the HONcode standard for trustworthy health information - You can buy ketoconazole creams and shampoos for topical use over-the-counter. Be careful with using too much of this or too often. Similarly, ketoconazole may modify the pharmacokinetics of other substances that share this metabolic pathway. If you are being treated with oral ketoconazole, your doctor has weighed the risks of you taking this medicine against the benefits it is expected to have for you.If you have been prescribed oral ketoconazole, do not stop using your medicine without first discussing it with your doctor. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Some patients had no obvious risk factors for liver disease. It is not possible to ascertain from the information available whether death was related to ketoconazole therapy or adrenal insufficiency in these patients with serious underlying disease.Anaphylaxis has been reported after the first dose. Cloborex, T-Gel, and Nizoral were all suggested by my dermatologist as options.

A lot of countries have banned this in oral form for Liver Damage (and that's one of the better things that can happen!). This occurred when ketoconazole was administered at doses higher than 10 mg/kg (about one fourth the maximum human dose, based on body surface area comparison).Ketoconazole has been shown to be excreted in the milk. acid neutralizing medicines such as aluminum hydroxide, or acid secretion suppressors such as HTherefore, administration of potent enzyme inducers of CYP3A4 with NizoralPotent inhibitors of CYP3A4 (e.g. Treatment should be continued until active fungal infection has subsided.In small numbers of children over 2 years of age, a single daily dose of 3.3 to 6.6 mg/kg has been used. Patients should be advised against alcohol consumption while on treatment.

Other substances that either share this metabolic pathway or modify CYP3A4 activity may influence the pharmacokinetics of ketoconazole. See Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, ranolazine. It is, therefore, advisable to monitor digoxin concentrations in patients receiving ketoconazole.Telithromycin: A multiple-dose interaction study with ketoconazole showed that CCilostazol: Concomitant administration of single doses of cilostazol 100 mg and ketoconazole 400 mg approximately doubled cilostazol concentrations and altered (increase/decrease) the concentrations of the active metabolites of cilostazol.Coumarins: Ketoconazole may enhance the anticoagulant effect of coumarin-like drugs, thus the anticoagulant effect should be carefully titrated and monitored.Dabigatran: In patients with moderate renal impairment (CrCL 50 mL/min to ≤ 80 mL/min), consider reducing the dose of dabigatran to 75 mg twice daily when it is coadministered with ketoconazole.Ergot alkaloids: The potential increase in plasma concentrations of ergot alkaloids when coadministered with NizoralEletriptan: Eletriptan should be used with caution with ketoconazole, and specifically, should not be used within at least 72 hours of treatment with ketoconazole.Irinotecan: The potential increase in plasma concentrations of irinotecan when coadministered with NizoralDocetaxel: In the presence of ketoconazole, the clearance of docetaxel in cancer patients was shown to decrease by 50%.Alprazolam, midazolam, triazolam: Coadministration of NizoralPimozide: The potential increase in plasma concentrations of pimozide when coadministered with NizoralAripiprazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15 mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively.

Most importantly, it works best for me as a shampoo. The potential increase in plasma concentrations of calcium channel blockers when co-administered with NizoralDihydropyridines: Concomitant administration of NizoralRanolazine: The potential increase in plasma concentrations of ranolazine when coadministered with NizoralBosentan: Coadministration of bosentan 125 mg twice daily and ketoconazole, increased the plasma concentrations of bosentan by approximately 2-fold in normal volunteers. See The Nizoral brand name has been discontinued in the U.S. Do not use NizoralThis Medication Guide summarizes the most important information about NizoralIf you would like more information, talk to your healthcare provider. Ketoconazole can cause elevated plasma concentrations of these drugs and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.

Nizoral Topical (ketoconazole): “Nizoral is purchased over the counter and is much cheaper than Cloborex. Nizoral® is a synthetic broad-spectrum antifungal agent available in scored white tablets, each containing 200 mg ketoconazole base for oral administration.